Teléfono: +34 876 553 510
Email: ebolea@unizar.es
Dirección: c/Pedro Cerbuna 12, Universidad de Zaragoza, Facultad de Ciencias, Departamento de Química Analítica – Zaragoza (España)
SOBRE MÍ
Eduardo Bolea Fernández obtuvo su Licenciatura y Máster en Química por la Universidad de Zaragoza, España. Llevó a cabo su investigación de doctorado en la Universidad de Gante, Bélgica, y obtuvo su título de Doctor en 2017. Su doctorado estaba enfocado en el desarrollo de nuevos métodos para el análisis elemental e isotópico de ultra-trazas utilizando espectrometría de masas-ICP en tándem (ICP-MS/MS). En octubre de 2017, Eduardo obtuvo una beca de investigación postdoctoral (BOF-UGent) centrada en el análisis isotópico de mercurio de alta precisión utilizando espectrometría de masas-ICP multi-colector con el objetivo de descifrar su ciclo biogeoquímico. En abril de 2018, ganó el Premio Internacional 2018 IUPAC-Solvay para Jóvenes Químicos entregado a las mejores tesis doctorales en ciencias químicas a nivel mundial. En noviembre de 2019, comenzó una beca de investigación postdoctoral junior (FWO) basada en el desarrollo de nuevos métodos analíticos y su aplicación en metalómica y nanotecnología. En enero de 2022, ganó el prestigioso premio “Young Scientist Winter Conference Award in Plasma Spectrochemistry” por sus contribuciones en este campo. En noviembre de 2022, comenzó una beca de investigación postdoctoral senior (FWO) enfocada en el análisis individual de células. En enero de 2023, fue galardonado con un contrato Ramón y Cajal (Ministerio de Ciencia e Innovación, Gobierno de España).
Hasta ahora, Eduardo es (co-)autor de 39 publicaciones en revistas internacionales y su trabajo ha sido presentado en >50 charlas en conferencias internacionales y workshops.
PUBLICACIONES
2024
Suárez-Criado, Laura; Bolea-Fernandez, Eduardo; Abou-Zeid, Lana; Vandermeiren, Mathias; Rodríguez-González, Pablo; Alonso, Jose Ignacio Garcia; Vanhaecke, Frank
En: J. Anal. At. Spectrom., vol. 39, iss. 2, pp. 592-600, 2024.
@article{D3JA00414G,
title = {Extending the application range of Hg isotopic analysis to sub-μg L−1 levels using cold vapor generation multi-collector inductively coupled plasma-mass spectrometry with 1013 ohm Faraday cup amplifiers},
author = {Laura Suárez-Criado and Eduardo Bolea-Fernandez and Lana Abou-Zeid and Mathias Vandermeiren and Pablo Rodríguez-González and Jose Ignacio Garcia Alonso and Frank Vanhaecke},
url = {http://dx.doi.org/10.1039/D3JA00414G},
doi = {10.1039/D3JA00414G},
year = {2024},
date = {2024-01-01},
urldate = {2024-01-01},
journal = {J. Anal. At. Spectrom.},
volume = {39},
issue = {2},
pages = {592-600},
publisher = {The Royal Society of Chemistry},
abstract = {High-precision determination of the isotopic composition of mercury (Hg) is of paramount importance for unraveling its biogeochemical cycle and for identifying the origin of Hg in environmental compartments. Cold vapor generation multi-collector inductively coupled plasma-mass spectrometry (CVG-MC-ICP-MS) is the standard approach for such application. Cold vapor generation provides a high Hg introduction efficiency into the ICP, while chromatographic Hg isolation is not required as a result of the selective reaction between Hg2+ and SnCl2. For environmental or biota samples with low Hg concentrations, however, this approach still presents challenges and reliable measurements typically require a Hg concentration ≥1 μg L−1 in the solution analyzed. Recent improvements of MC-ICP-MS instrumentation, including the introduction of the so-called Jet interface and 1013 Ω Faraday cup amplifiers, enhance the signal-to-noise ratio. In this study, it was investigated to what extent this allows Hg isotopic analysis at lower concentration. Performance in Hg isotopic analysis was compared using two different sets of cones (standard vs. Jet), two plasma conditions (wet vs. dry) and two amplifier types (1011 Ω vs. 1013 Ω). Satisfactory accuracy and precision were achieved at a Hg concentration down to 0.1 μg L−1 in the solution measured when using Jet cones, dry plasma conditions, and the four available 1013 Ω amplifiers. The uncertainty expressed as 2SD for the δ202Hg values measured for the in-house standard solution was ±0.2‰ at 0.25 μg Hg L−1 and ± 0.3‰ at 0.1 μg Hg L−1. The method was subsequently applied to the analysis of real surface water samples contaminated with toxic metals.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Rua-Ibarz, Ana; Acker, Thibaut Van; Bolea-Fernandez, Eduardo; Boccongelli, Marina; Vanhaecke, Frank
A comparison of calibration strategies for quantitative laser ablation ICP-mass spectrometry (LA-ICP-MS) analysis of fused catalyst samples Artículo de revista
En: J. Anal. At. Spectrom., vol. 39, iss. 3, pp. 888-899, 2024.
@article{D3JA00271C,
title = {A comparison of calibration strategies for quantitative laser ablation ICP-mass spectrometry (LA-ICP-MS) analysis of fused catalyst samples},
author = {Ana Rua-Ibarz and Thibaut Van Acker and Eduardo Bolea-Fernandez and Marina Boccongelli and Frank Vanhaecke},
url = {http://dx.doi.org/10.1039/D3JA00271C},
doi = {10.1039/D3JA00271C},
year = {2024},
date = {2024-01-01},
urldate = {2024-01-01},
journal = {J. Anal. At. Spectrom.},
volume = {39},
issue = {3},
pages = {888-899},
publisher = {The Royal Society of Chemistry},
abstract = {In the field of petrochemistry, the quantitative determination of trace elements in catalysts is crucial for optimizing various types of processes. Catalyst poisoning, resulting from the presence of contaminants, can lead to decreased performance and efficiency, even when these are present at trace level only. Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technique for trace elemental analysis, but its application to catalysts is challenging due to their physicochemical characteristics challenging straightforward dissolution. Laser ablation (LA) coupled to ICP-MS (LA-ICP-MS) has emerged as a valuable approach for direct analysis of solid samples. However, developing an appropriate calibration strategy for reliable quantitative LA-ICP-MS analysis of catalyst samples remains a challenge. In this work, different calibration strategies for quantitative LA-ICP-MS analysis of fused catalyst samples were evaluated. The traditional strategy relied on external calibration against certified reference materials (CRMs) combined with internal standardization and was considered the reference approach. When using this approach, the relative bias with respect to the reference value was found to be <15%. Two novel calibration strategies were introduced and compared: a so-called multi-signal calibration approach and a solution-based calibration approach. The multi-signal calibration strategy involved varying the laser repetition rate (20, 30, 40 and 50 Hz) or laser beam diameter (10, 12, 15 and 20 μm), allowing a calibration curve to be constructed by comparing the analytical signal intensity for a single solid CRM with that for the sample, thus partially overcoming the shortage of CRMs for quantitative LA-ICP-MS analysis. The solution-based calibration approach was used for quantitative multi-element analysis without the need for any solid standard and required only minor hardware modifications to accommodate the introduction of aqueous standard solutions for calibration. Various glass certified reference materials were used for method development, calibration, and validation purposes. Furthermore, two fused alumina catalyst samples (used in the context of petroleum refining processes) were successfully analyzed as a proof-of-concept application. For both the multi-signal (matrix-matched conditions) and the solution-based calibration approaches, the average relative bias between the experimentally determined and certified/reference concentrations varied between −9% and +7%.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bolea-Fernandez, Eduardo; Rua-Ibarz, Ana; Anjos, Jorge Alves; Vanhaecke, Frank
En: Talanta, vol. 276, pp. 126210, 2024, ISSN: 0039-9140.
@article{BOLEAFERNANDEZ2024126210,
title = {Development and initial evaluation of a combustion-based sample introduction system for direct isotopic analysis of mercury in solid samples via multi-collector ICP-mass spectrometry},
author = {Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Jorge Alves Anjos and Frank Vanhaecke},
url = {https://www.sciencedirect.com/science/article/pii/S0039914024005897},
doi = {https://doi.org/10.1016/j.talanta.2024.126210},
issn = {0039-9140},
year = {2024},
date = {2024-01-01},
urldate = {2024-01-01},
journal = {Talanta},
volume = {276},
pages = {126210},
abstract = {High-precision isotopic analysis of mercury (Hg) using multi-collector ICP-mass spectrometry (MC-ICP-MS) is a powerful method for obtaining insight into the sources, pathways and sinks of this toxic metal. Modification of a commercially available mercury analyzer (Teledyne Leeman Labs, Hydra IIc – originally designed for quantification of Hg through sample combustion, collection of the Hg vapor on a gold amalgamator, subsequent controlled release of Hg and detection using cold vapor atomic absorption spectrometry CVAAS) enabled the system to be used for the direct high-precision Hg isotopic analysis of solid samples using MC-ICP-MS – i.e., without previous sample digestion and subsequent dilution. The changes made to the mercury analyzer did not compromise its (simultaneous) use for Hg quantification via CVAAS. The Hg vapor was mixed with a Tl-containing aerosol produced via pneumatic nebulization, creating wet plasma conditions, and enabling the use of Tl as an internal standard for correction of instrumental mass discrimination. Accurate and precise (0.10 ‰ 2SD, δ202Hg},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Freire, Bruna Moreira; Rua-Ibarz, Ana; Nakadi, Flávio Venâncio; Bolea-Fernandez, Eduardo; Barriuso-Vargas, Juan J.; Lange, Camila Neves; Aramendía, Maite; Batista, Bruno Lemos; Resano, Martín
Tracing isotopically labeled selenium nanoparticles in plants via single-particle ICP-mass spectrometry Artículo de revista
En: Talanta, vol. 277, pp. 126417, 2024, ISSN: 0039-9140.
@article{FREIRE2024126417,
title = {Tracing isotopically labeled selenium nanoparticles in plants via single-particle ICP-mass spectrometry},
author = {Bruna Moreira Freire and Ana Rua-Ibarz and Flávio Venâncio Nakadi and Eduardo Bolea-Fernandez and Juan J. Barriuso-Vargas and Camila Neves Lange and Maite Aramendía and Bruno Lemos Batista and Martín Resano},
url = {https://www.sciencedirect.com/science/article/pii/S0039914024007963},
doi = {https://doi.org/10.1016/j.talanta.2024.126417},
issn = {0039-9140},
year = {2024},
date = {2024-01-01},
journal = {Talanta},
volume = {277},
pages = {126417},
abstract = {Abstract
Agronomic biofortification using selenium nanoparticles (SeNPs) shows potential for addressing selenium deficiency but further research on SeNPs-plants interaction is required before it can be effectively used to improve nutritional quality. In this work, single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) was used for tracing isotopically labeled SeNPs (82SeNPs) in Oryza sativa L. tissues. For this purpose, SeNPs with natural isotopic abundance and 82SeNPs were synthesized by a chemical method. The NPs characterization by transmission electron microscopy (TEM) confirmed that enriched NPs maintained the basic properties of unlabeled NPs, showing spherical shape, monodispersity, and sizes in the nano-range (82.8 ± 6.6 nm and 73.2 ± 4.4 nm for SeNPs and 82SeNPs, respectively). The use of 82SeNPs resulted in an 11-fold enhancement in the detection power for ICP-MS analysis, accompanied by an improvement in the signal-to-background ratio and a reduction of the size limits of detection from 89.9 to 39.9 nm in SP-ICP-MS analysis. This enabled 82SeNPs to be tracked in O. sativa L. plants cultivated under foliar application of 82SeNPs. Tracing studies combining SP-ICP-MS and TEM-energy-dispersive X-ray spectroscopy data confirmed the uptake of intact 82SeNPs by rice leaves, with most NPs remaining in the leaves and very few particles translocated to shoots and roots. Translocation of Se from leaves to roots and shoots was found to be lower when applied as NPs compared to selenite application. From the size distributions, as obtained by SP-ICP-MS, it can be concluded that a fraction of the 82SeNPs remained within the same size range as that of the applied NP suspension, while other fraction underwent an agglomeration process in the leaves, as confirmed by TEM images. This illustrates the potential of SP-ICP-MS analysis of isotopically enriched 82SeNPs for tracing NPs in the presence of background elements within complex plant matrices, providing important information about the uptake, accumulation, and biotransformation of SeNPs in rice plants.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Agronomic biofortification using selenium nanoparticles (SeNPs) shows potential for addressing selenium deficiency but further research on SeNPs-plants interaction is required before it can be effectively used to improve nutritional quality. In this work, single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) was used for tracing isotopically labeled SeNPs (82SeNPs) in Oryza sativa L. tissues. For this purpose, SeNPs with natural isotopic abundance and 82SeNPs were synthesized by a chemical method. The NPs characterization by transmission electron microscopy (TEM) confirmed that enriched NPs maintained the basic properties of unlabeled NPs, showing spherical shape, monodispersity, and sizes in the nano-range (82.8 ± 6.6 nm and 73.2 ± 4.4 nm for SeNPs and 82SeNPs, respectively). The use of 82SeNPs resulted in an 11-fold enhancement in the detection power for ICP-MS analysis, accompanied by an improvement in the signal-to-background ratio and a reduction of the size limits of detection from 89.9 to 39.9 nm in SP-ICP-MS analysis. This enabled 82SeNPs to be tracked in O. sativa L. plants cultivated under foliar application of 82SeNPs. Tracing studies combining SP-ICP-MS and TEM-energy-dispersive X-ray spectroscopy data confirmed the uptake of intact 82SeNPs by rice leaves, with most NPs remaining in the leaves and very few particles translocated to shoots and roots. Translocation of Se from leaves to roots and shoots was found to be lower when applied as NPs compared to selenite application. From the size distributions, as obtained by SP-ICP-MS, it can be concluded that a fraction of the 82SeNPs remained within the same size range as that of the applied NP suspension, while other fraction underwent an agglomeration process in the leaves, as confirmed by TEM images. This illustrates the potential of SP-ICP-MS analysis of isotopically enriched 82SeNPs for tracing NPs in the presence of background elements within complex plant matrices, providing important information about the uptake, accumulation, and biotransformation of SeNPs in rice plants.
2023
Acker, Thibaut Van; Rua-Ibarz, Ana; Vanhaecke, Frank; Bolea-Fernandez, Eduardo
Laser Ablation for Nondestructive Sampling of Microplastics in Single-Particle ICP-Mass Spectrometry Artículo de revista
En: Anal. Chem., vol. 95, iss. 50, pp. 18579-18586, 2023.
@article{nokey,
title = {Laser Ablation for Nondestructive Sampling of Microplastics in Single-Particle ICP-Mass Spectrometry},
author = {Thibaut Van Acker and Ana Rua-Ibarz and Frank Vanhaecke and Eduardo Bolea-Fernandez},
url = {https://doi.org/10.1021/acs.analchem.3c04473},
doi = {10.1021/acs.analchem.3c04473},
year = {2023},
date = {2023-12-05},
urldate = {2023-12-05},
journal = {Anal. Chem.},
volume = {95},
issue = {50},
pages = {18579-18586},
abstract = {In this work, laser ablation (LA) was characterized as a method for sampling and introducing microplastic particles (MPs) into an inductively coupled plasma (ICP) for subsequent 13C+ monitoring using an ICP-mass spectrometer operated in single-event mode. MPs of different types (PS, PMMA, and PVC) and sizes (2–20 μm) were introduced intactly. The laser energy density did not affect the particle sampling across a wide range (0.25–6.00 J cm–2). Single-shot analysis separated clustered MPs (2–7 MPs per cluster) during the LA and particle transport processes, allowing the temporally resolved analysis of the individual constituting MPs. Line scanning showed superior performance when using a small laser beam diameter combined with a high repetition rate. The 13C+ signal intensity correlated linearly (R2 >0.9945) with the absolute C mass in a 2–10 μm size range, while the use of He in the collision-reaction cell (CRC) allowed extension of the linear range to 20 μm. The LA approach generated narrower 13C+ signal distributions than the traditional solution-based approach (dry versus wet plasma conditions) and proved successful for the analysis of a mixed suspension (containing four sizes of PS MPs in a 2–5 μm size range) and for sampling MPs from PVDF and glass microfiber filters, with the latter offering a lower background.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}