Esperanza García Ruiz

@article{RESANO201875,

title = {Dried matrix spots and clinical elemental analysis. Current status, difficulties, and opportunities},

author = {M. Resano and M. A. Belarra and E. García-Ruiz and M. Aramendía and L. Rello},

url = {https://www.sciencedirect.com/science/article/pii/S0165993617302650},

doi = {https://doi.org/10.1016/j.trac.2017.12.004},

issn = {0165-9936},

year  = {2018},

date = {2018-01-01},

journal = {TrAC Trends in Analytical Chemistry},

volume = {99},

pages = {75-87},

abstract = {This article examines the increasing importance of dried matrix spots (DMS), such as dried blood spots, dried urine spots, etc., in biomedical research, the challenges associated with their analysis when quantitative elemental information is aimed at, as well as the benefits deriving from the further usage of these types of samples. The article briefly reviews the historical evolution of this sampling approach in elemental clinical analysis, stressing prospective areas of applications (e.g., newborns or prosthesis control), the methodologies most recently developed to produce DMS of known volume, as well as novel strategies proposed to analyze them, often related to direct solid sampling techniques or fast lixiviation methods. Finally, the article discusses the type of information that could be obtained after isotopic analysis of DMS when targeting non-traditional stable isotopes (e.g., Cu, Fe or Zn), which can significantly help in the early diagnosis of some medical conditions (e.g. Wilson's disease).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{MARGUI201813,

title = {Energy dispersive X-ray fluorescence spectrometry for the direct multi-element analysis of dried blood spots},

author = {E. Marguí and I. Queralt and E. García-Ruiz and E. García-González and L. Rello and M. Resano},

url = {https://www.sciencedirect.com/science/article/pii/S0584854717303129},

doi = {https://doi.org/10.1016/j.sab.2017.11.003},

issn = {0584-8547},

year  = {2018},

date = {2018-01-01},

journal = {Spectrochimica Acta Part B: Atomic Spectroscopy},

volume = {139},

pages = {13-19},

abstract = {Home-based collection protocols for clinical specimens are actively pursued as a means of improving life quality of patients. In this sense, dried blood spots (DBS) are proposed as a non-invasive and even self-administered alternative to sampling whole venous blood. This contribution explores the potential of energy dispersive X-ray fluorescence spectrometry for the simultaneous and direct determination of some major (S, Cl, K, Na), minor (P, Fe) and trace (Ca, Cu, Zn) elements in blood, after its deposition onto clinical filter papers, thus giving rise to DBS. For quantification purposes the best strategy was to use matrix-matched blood samples of known analyte concentrations. The accuracy and precision of the method were evaluated by analysis of a blood reference material (Seronorm™ trace elements whole blood L3). Quantitative results were obtained for the determination of P, S, Cl, K and Fe, and limits of detection for these elements were adequate, taking into account their typical concentrations in real blood samples. Determination of Na, Ca, Cu and Zn was hampered by the occurrence of high sample support (Na, Ca) and instrumental blanks (Cu, Zn). Therefore, the quantitative determination of these elements at the levels expected in blood samples was not feasible. The methodology developed was applied to the analysis of several blood samples and the results obtained were compared with those reported by standard techniques. Overall, the performance of the method developed is promising and it could be used to determine the aforementioned elements in blood samples in a simple, fast and economic way. Furthermore, its non-destructive nature enables further analyses by means of complementary techniques to be carried out.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{C7JA00210F,

title = {Cerebrospinal fluid elemental analysis by using a total sample consumption system operated at high temperature adapted to inductively coupled plasma mass spectrometry},

author = {Águeda Cañabate and Esperanza García-Ruiz and Martín Resano and José-Luis Todolí},

url = {http://dx.doi.org/10.1039/C7JA00210F},

doi = {10.1039/C7JA00210F},

year  = {2017},

date = {2017-01-01},

journal = {J. Anal. At. Spectrom.},

volume = {32},

issue = {10},

pages = {1916-1924},

publisher = {The Royal Society of Chemistry},

abstract = {A total consumption low sample introduction system has been applied for the first time to the multielement analysis of non-diluted cerebrospinal fluids (CSFs) by means of inductively coupled plasma mass spectrometry (ICP-MS). A 2.5 μL sample volume has been injected into an air carrier stream in agreement with the air-segmented injection principle. The sample plug has been turned into an aerosol by means of a high efficiency nebulizer (HEN) and further introduced into the so-called high temperature torch integrated sample introduction system (hTISIS). A transient signal has been thus obtained. For spiked CSF real samples it has been verified that the higher the temperature, the greater the sensitivity. Under optimized conditions, the hTISIS provides peak areas around four times higher than those provided by the spectrometer default device (i.e., a double pass spray chamber). Additional advantages provided by the former system include limits of detection up to 6 times lower and narrower peaks as compared to those reported for the double pass spray chamber. Furthermore, the use of the hTISIS is not detrimental from the point of view oxide production and doubly charged ion generation. Regarding the extent of non-spectral interference caused by the CSF matrix, it has been verified that, with the hTISIS, recoveries for spiked real samples were close to 100% for a set of 14 different elements (V, Cr, Mn, Co, Ni, Cu, As, Se, Mo, Cd, Sb, Ba, Tl and Pb). Meanwhile, in segmented flow injection mode, the reference system provided recoveries from 200 to 500%, depending on the element and the sample, thus demonstrating the occurrence of matrix effects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{C6JA00374E,

title = {Analysis of whole blood by ICP-MS equipped with a high temperature total sample consumption system},

author = {Águeda Cañabate and Esperanza García-Ruiz and Martín Resano and José-Luis Todolí},

url = {http://dx.doi.org/10.1039/C6JA00374E},

doi = {10.1039/C6JA00374E},

year  = {2017},

date = {2017-01-01},

journal = {J. Anal. At. Spectrom.},

volume = {32},

issue = {1},

pages = {78-87},

publisher = {The Royal Society of Chemistry},

abstract = {In this work, the performance of a high temperature torch Integrated Sample Introduction System (hTISIS) using inductively coupled plasma mass spectrometry (ICP-MS) for the multi-element analysis of whole blood is evaluated. Two different quadrupole-based spectrometers were tested and the optimization studies were performed with a reference whole blood material. Sample dilution factor and hTISIS temperature were taken as the variables. The sample was introduced following two different procedures: continuous aspiration and air-segmentation. The optimum performance of the system in terms of both analytical figures of merit and accuracy was obtained for a hTISIS temperature of 200 °C and for either 1 : 10 or 1 : 25 dilution factors depending on the ICP-MS device used. An improvement in terms of sensitivity and detection limits was obtained with the hTISIS as compared to the conventional cyclonic spray chamber. Thus, for 1 : 25 diluted blood samples, the hTISIS improved the sensitivity by a factor ranging 2.0–4.5. Moreover, at 200 °C, the limits of detection for hTISIS at 200 °C were 1.1 to 8.4 times lower than those for the cyclonic spray chamber. This analytical parameter was in the ng L−1 range for the detected elements. Matrix effects in turn became less severe as the hTISIS temperature increased (from room temperature to 80 °C). All these results were obtained without a severe degradation of the fundamental plasma parameters. In fact, under optimum conditions BaO+/Ba+ and Ba2+/Ba+ signal ratios were 1.2% and 2.0%, respectively. The developed method was applied for the analysis of low volumes (ca. 2.5 μL) of real blood samples after a minimally invasive collection by volumetric absorptive microsampling. The hTISIS is an easy-to-implement sample introduction system that can be employed for the routine analysis using ICP-MS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{GUARDA2017354,

title = {Determination of chlorine via the CaCl molecule by high-resolution continuum source graphite furnace molecular absorption spectrometry and direct solid sample analysis},

author = {Ananda Guarda and Maite Aramendía and Irene Andrés and Esperanza García-Ruiz and Paulo Cícero Nascimento and Martín Resano},

url = {https://www.sciencedirect.com/science/article/pii/S0039914016307913},

doi = {https://doi.org/10.1016/j.talanta.2016.10.039},

issn = {0039-9140},

year  = {2017},

date = {2017-01-01},

journal = {Talanta},

volume = {162},

pages = {354-361},

abstract = {This work investigates the possibilities of high-resolution continuum source graphite furnace molecular absorption spectrometry for the direct determination of Cl in solid samples via the CaCl molecule and measurement of its molecular absorption. The method proposed is based on addition of 400µg Ca as molecule-forming reagent and of 20µgPd as chemical modifier, which helps to stabilize the analyte and enhances sensitivity. The molecular spectrum for CaCl offers different lines with different limits of detection and linear ranges, which permitted to analyze solid samples with different Cl contents. The lowest limit of detection (0.75ng Cl, corresponding to 0.75µgg−1 for a typical sample mass of 1mg) could be achieved by combination of three of the most sensitive lines in the vicinity of 620.862nm, while the amplest linear range (up to 860ng Cl) was achieved by selection of the less sensitive line at 377.501nm. The method developed enabled the direct determination of Cl in solid samples using simple external calibration with aqueous standards. Good precision (5–9% RSD) and accuracy was attained in a series of certified samples of very different nature (i.e. coal, iron oxide, polyethylene, human hair, pine needles, rice flour and milk) and with very different Cl contents, ranging from about 50µgg−1 to 1% (w/w) Cl. The method appears as particularly useful for Cl determination in samples with elevated Ca contents, for which biased results with other diatomic molecules, such as AlCl or SrCl, may be obtained.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}