{"id":3838,"date":"2023-02-20T17:22:57","date_gmt":"2023-02-20T15:22:57","guid":{"rendered":"https:\/\/marte.i3a.es\/?p=3838"},"modified":"2024-01-22T11:44:49","modified_gmt":"2024-01-22T09:44:49","slug":"antonio-bazo-sanchez","status":"publish","type":"post","link":"https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/","title":{"rendered":"Antonio Bazo S\u00e1nchez"},"content":{"rendered":"<div id=\"pl-gb3838-69ed8abd5db84\"  class=\"panel-layout\" ><div id=\"pg-gb3838-69ed8abd5db84-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb3838-69ed8abd5db84-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb3838-69ed8abd5db84-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3838-69ed8abd5db84-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-93415d0e2dbf-3838 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"\/es\/.\/team\/\">Investigadores<\/a><\/h3>\n<h1 style=\"text-align: center\"><strong>Antonio Bazo S\u00e1nchez<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb3838-69ed8abd5e778\"  class=\"panel-layout\" ><div id=\"pg-gb3838-69ed8abd5e778-0\"  class=\"panel-grid panel-no-style\" ><div 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><div id=\"panel-gb3838-69ed8abd5e778-0-1-0\" class=\"so-panel widget widget_sow-image-grid panel-first-child\" data-index=\"1\" ><div class=\"panel-widget-style panel-widget-style-for-gb3838-69ed8abd5e778-0-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-image-grid so-widget-sow-image-grid-default-5ff4073610f5-3838\"\n\t\t\t\n\t\t>\t<div\n\t\tclass=\"sow-image-grid-wrapper\"\n\t\tdata-max-width=\"37\"\t\tdata-max-height=\"37\"\t>\n\t\t\t\t\t<div class=\"sow-image-grid-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/es.linkedin.com\/in\/antonio-bazo\"\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\" \t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer\" \t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/linkedin.png\" class=\"sow-image-grid-image_html\" alt=\"\" title=\"LinkedIn\" srcset=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/linkedin.png 37w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/linkedin-12x12.png 12w\" sizes=\"auto, (max-width: 37px) 100vw, 37px\" \/>\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"sow-image-grid-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/orcid.org\/0000-0003-1603-2691\"\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\" \t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer\" \t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2022\/03\/ORCID_iD.svg_-150x150.png\" class=\"sow-image-grid-image_html\" alt=\"\" title=\"ORCID\" srcset=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2022\/03\/ORCID_iD.svg_-150x150.png 150w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2022\/03\/ORCID_iD.svg_-300x300.png 300w, 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href=\"https:\/\/www.instagram.com\/antonio.bazo\/\"\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\" \t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer\" \t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/instagram.png\" class=\"sow-image-grid-image_html\" alt=\"\" title=\"Instagram\" srcset=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/instagram.png 37w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2020\/10\/instagram-12x12.png 12w\" sizes=\"auto, (max-width: 37px) 100vw, 37px\" \/>\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-gb3838-69ed8abd5e778-0-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Tel\u00e9fono:<\/strong> +34 876 553 510<\/p>\n<p><strong>Email:<\/strong> <a href=\"mailto:abazo13@gmail.com\">abazo13@gmail.com<\/a><\/p>\n<p><strong>Direcci\u00f3n:<\/strong> c\/Pedro Cerbuna 12, Universidad de Zaragoza, Facultad de Ciencias, Departamento de Qu\u00edmica Anal\u00edtica \u2013 Zaragoza (Espa\u00f1a)<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb3838-69ed8abd60872\"  class=\"panel-layout\" ><div id=\"pg-gb3838-69ed8abd60872-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-gb3838-69ed8abd60872-0\" ><div id=\"pgc-gb3838-69ed8abd60872-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3838-69ed8abd60872-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-244eb6bef45a-3838\"\n\t\t\t\n\t\t><div class=\"sow-headline-container\">\n\t\t\t\t\t\t\t<h5 class=\"sow-headline\">\n\t\t\t\t\t\tSOBRE M\u00cd\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n<\/div><\/div><div id=\"panel-gb3838-69ed8abd60872-0-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div><span style=\"font-family: arial, sans-serif;\">Antonio Bazo S\u00e1nchez obtuvo su licenciatura en Qu\u00edmica en la Universidad de Zaragoza (Espa\u00f1a) en 2020. Tras obtener un m\u00e1ster en Materiales Nanoestructurados para Aplicaciones en Nanotecnolog\u00eda en la misma Universidad, actualmente es estudiante de doctorado en el Departamento de Qu\u00edmica Anal\u00edtica en el grupo de investigaci\u00f3n \"M\u00e9todos R\u00e1pidos de An\u00e1lisis con T\u00e9cnicas Espectrosc\u00f3picas \u2013 MARTE\". Su investigaci\u00f3n se centra en los fundamentos y aplicaciones de la espectrometr\u00eda de masas ICP con detecci\u00f3n de part\u00edculas\/c\u00e9lulas \u00fanicas (SP\/SC-ICP-MS).<\/span>\u00a0La defensa p\u00fablica de su tesis doctoral est\u00e1 prevista para 2026.<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-gb3838-69ed8abd60872-1\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-gb3838-69ed8abd60872-1\" ><div id=\"pgc-gb3838-69ed8abd60872-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3838-69ed8abd60872-1-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-244eb6bef45a-3838\"\n\t\t\t\n\t\t><div class=\"sow-headline-container\">\n\t\t\t\t\t\t\t<h5 class=\"sow-headline\">\n\t\t\t\t\t\tPUBLICACIONES\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n<\/div><\/div><div id=\"panel-gb3838-69ed8abd60872-1-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\" action=\"\"><a name=\"tppubs\" id=\"tppubs\"><\/a><div class=\"teachpress_filter\"><select class=\"default\" name=\"yr\" id=\"yr\" tabindex=\"2\" onchange=\"teachpress_jumpMenu('parent',this, 'https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?')\">\r\n                   <option value=\"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=#tppubs\">Todos los a\u00f1os<\/option>\r\n                   <option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2025#tppubs\" >2025<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2024#tppubs\" >2024<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2023#tppubs\" >2023<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2022#tppubs\" >2022<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2021#tppubs\" >2021<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2020#tppubs\" >2020<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2019#tppubs\" >2019<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2018#tppubs\" >2018<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2017#tppubs\" >2017<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2016#tppubs\" >2016<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2015#tppubs\" >2015<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2014#tppubs\" >2014<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2013#tppubs\" >2013<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2012#tppubs\" >2012<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2004#tppubs\" >2004<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=0000#tppubs\" >0000<\/option>\r\n                <\/select><select class=\"default\" name=\"type\" id=\"type\" tabindex=\"3\" onchange=\"teachpress_jumpMenu('parent',this, 'https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?')\">\r\n                   <option value=\"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=#tppubs\">Todas las tipolog\u00edas<\/option>\r\n                   <option value = \"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=article#tppubs\" >Art\u00edculos de revista<\/option><option value = \"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=proceedings#tppubs\" >Actas de congresos<\/option>\r\n                <\/select><\/div><input type=\"hidden\" name=\"trp-form-language\" value=\"es\"\/><\/form><div class=\"tablenav\"><div class=\"tablenav-pages\"><span class=\"displaying-num\">12 registros<\/span> <a class=\"page-numbers button disabled\">&laquo;<\/a> <a class=\"page-numbers button disabled\">&lsaquo;<\/a> 1 de 3 <a href=\"https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?limit=2&amp;tgid=&amp;yr=&amp;type=&amp;usr=&amp;auth=&amp;tsr=#tppubs\" title=\"p\u00e1gina siguiente\" class=\"page-numbers button\">&rsaquo;<\/a> <a href=\"https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?limit=3&amp;tgid=&amp;yr=&amp;type=&amp;usr=&amp;auth=&amp;tsr=#tppubs\" title=\"\u00faltima p\u00e1gina\" class=\"page-numbers button\">&raquo;<\/a> <\/div><\/div><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2025\">2025<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Rua-Ibarz, Ana;  Nakadi, Fl\u00e1vio V.;  Bolea-Fernandez, Eduardo;  Bazo, Antonio;  Battistella, Beatrice;  Matiushkina, Anna;  Resch-Genger, Ute;  Abad, Carlos;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('262','tp_links')\" style=\"cursor:pointer;\">Discrete Entity Analysis via Microwave-Induced Nitrogen Plasma\u2013Mass Spectrometry in Single-Event Mode<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Analytical Chemistry, <\/span><span class=\"tp_pub_additional_volume\">vol. 0, <\/span><span class=\"tp_pub_additional_number\">no 0, <\/span><span class=\"tp_pub_additional_pages\">pp. null, <\/span><span class=\"tp_pub_additional_year\">2025<\/span><span class=\"tp_pub_additional_note\">, (PMID: 41084806)<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_262\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{,<br \/>\r\ntitle = {Discrete Entity Analysis via Microwave-Induced Nitrogen Plasma\u2013Mass Spectrometry in Single-Event Mode},<br \/>\r\nauthor = {Ana Rua-Ibarz and Fl\u00e1vio V. Nakadi and Eduardo Bolea-Fernandez and Antonio Bazo and Beatrice Battistella and Anna Matiushkina and Ute Resch-Genger and Carlos Abad and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/doi.org\/10.1021\/acs.analchem.5c04341},<br \/>\r\ndoi = {10.1021\/acs.analchem.5c04341},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-10-14},<br \/>\r\nurldate = {2025-10-14},<br \/>\r\njournal = {Analytical Chemistry},<br \/>\r\nvolume = {0},<br \/>\r\nnumber = {0},<br \/>\r\npages = {null},<br \/>\r\nabstract = {In this work, single-event microwave-induced nitrogen plasma\u2013mass spectrometry (single-event MINP-MS) was evaluated for the first time for the analysis of discrete entities such as nanoparticles, biological cells, and microplastics. Nitrogen (N2) effectively overcomes Ar-based polyatomic interferences, enabling (ultra)trace element determination of Fe and Se using their most abundant isotopes, 56Fe (91.66%) and 80Se (49.82%). Iron oxide nanoparticles (Fe2O3 NPs) ranging from 20 to 70 nm were accurately characterized, with excellent agreement with established sizing techniques, such as transmission electron microscopy (TEM) and dynamic light scattering (DLS). A limit of detection (LoD) of 8.6 ag for Fe\u2500equivalent to an LoDsize of 19 nm for Fe2O3\u2500was achieved, which is significantly lower than recent values reported for high-end quadrupole-based ICP-MS. Selenium nanoparticles (SeNPs) of 150 and 250 nm were also accurately characterized, without the N2-based plasma experiencing issues handling relatively large metallic NPs (linearity, R2 = 0.9994). Se-enriched yeast cells (SELM-1 certified reference material) were successfully analyzed via single-cell MINP-MS using external calibration based on SeNPs and a transport efficiency-independent approach. In addition, 2\u20133 \u03bcm polystyrene (PS) and polytetrafluoroethylene (PTFE) were accurately sized by monitoring 12C+, confirming the method\u2019s suitability for handling micrometer-sized polymeric materials (microplastics). The average duration of individual events (680 \u00b1 160 \u03bcs) suggests that the digestion of individual entities in N2-based plasmas is comparable to that in Ar-based plasmas. These results open new avenues for this instrumentation as an alternative to ICP ionization sources, also in the context of discrete entity analysis.},<br \/>\r\nnote = {PMID: 41084806},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_262\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In this work, single-event microwave-induced nitrogen plasma\u2013mass spectrometry (single-event MINP-MS) was evaluated for the first time for the analysis of discrete entities such as nanoparticles, biological cells, and microplastics. Nitrogen (N2) effectively overcomes Ar-based polyatomic interferences, enabling (ultra)trace element determination of Fe and Se using their most abundant isotopes, 56Fe (91.66%) and 80Se (49.82%). Iron oxide nanoparticles (Fe2O3 NPs) ranging from 20 to 70 nm were accurately characterized, with excellent agreement with established sizing techniques, such as transmission electron microscopy (TEM) and dynamic light scattering (DLS). A limit of detection (LoD) of 8.6 ag for Fe\u2500equivalent to an LoDsize of 19 nm for Fe2O3\u2500was achieved, which is significantly lower than recent values reported for high-end quadrupole-based ICP-MS. Selenium nanoparticles (SeNPs) of 150 and 250 nm were also accurately characterized, without the N2-based plasma experiencing issues handling relatively large metallic NPs (linearity, R2 = 0.9994). Se-enriched yeast cells (SELM-1 certified reference material) were successfully analyzed via single-cell MINP-MS using external calibration based on SeNPs and a transport efficiency-independent approach. In addition, 2\u20133 \u03bcm polystyrene (PS) and polytetrafluoroethylene (PTFE) were accurately sized by monitoring 12C+, confirming the method\u2019s suitability for handling micrometer-sized polymeric materials (microplastics). The average duration of individual events (680 \u00b1 160 \u03bcs) suggests that the digestion of individual entities in N2-based plasmas is comparable to that in Ar-based plasmas. These results open new avenues for this instrumentation as an alternative to ICP ionization sources, also in the context of discrete entity analysis.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_262\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/doi.org\/10.1021\/acs.analchem.5c04341\" title=\"https:\/\/doi.org\/10.1021\/acs.analchem.5c04341\" target=\"_blank\">https:\/\/doi.org\/10.1021\/acs.analchem.5c04341<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1021\/acs.analchem.5c04341\" title=\"DOI de seguimiento:10.1021\/acs.analchem.5c04341\" target=\"_blank\">doi:10.1021\/acs.analchem.5c04341<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Aramend\u00eda, Maite;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('258','tp_links')\" style=\"cursor:pointer;\">Ions with Ions, Entities with Entities: A Proof-of-Concept Study Using the SELM-1 Yeast Certified Reference Material for Intra- and Extracellular Se Quantification via Single-Cell ICP-Mass Spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Anal. Chem., <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1520-6882<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_258\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Ions with Ions, Entities with Entities: A Proof-of-Concept Study Using the SELM-1 Yeast Certified Reference Material for Intra- and Extracellular Se Quantification via Single-Cell ICP-Mass Spectrometry},<br \/>\r\nauthor = {Antonio Bazo and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Maite Aramend\u00eda and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1021\/acs.analchem.5c01588},<br \/>\r\nissn = {1520-6882},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-06-07},<br \/>\r\nurldate = {2025-06-07},<br \/>\r\njournal = {Anal. Chem.},<br \/>\r\nabstract = {In this work, two novel nanoparticle (NP)-based calibration strategies, external calibration and a relative method, have been explored for single-cell ICP-mass spectrometry (SC-ICP-MS) analysis. The fundamental principle of these methods is to rely on individual entities (well-characterized NPs of the target analyte) for calibration rather than on ionic standard solutions. The performance of the NP-based calibration approaches has been compared to that of the reference method (particle size with AuNP standards). In addition to the intracellular Se content (mass per individual cell), the extracellular Se (dissolved fraction) was also determined directly and simultaneously using the average background from the SC-ICP-MS time-resolved signal. The figures-of-merit of the methods developed have been evaluated by relying on the analysis of the SELM-1 cell-certified reference material, consisting of Se-enriched yeast cells, and certified for its total Se content (intracellular + extracellular Se). All methods successfully determined the Se elemental contents, but an improvement in accuracy and precision was observed for the NP-based methods compared to the reference one. Furthermore, the NP-based methods were found to be less time-consuming, more straightforward, and more user-friendly in terms of calculations. These results open new avenues for calibration in quantitative SC-ICP-MS analysis and call for a fundamental change in the methodology, where the determination of ionic contents is based on the use of ionic standard solutions for calibration, while the determination of elemental contents in discrete micro\/nanoentities, such as cells, should ideally be based on calibration using standard entities, thus avoiding the need to calculate a transport efficiency coefficient.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_258\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In this work, two novel nanoparticle (NP)-based calibration strategies, external calibration and a relative method, have been explored for single-cell ICP-mass spectrometry (SC-ICP-MS) analysis. The fundamental principle of these methods is to rely on individual entities (well-characterized NPs of the target analyte) for calibration rather than on ionic standard solutions. The performance of the NP-based calibration approaches has been compared to that of the reference method (particle size with AuNP standards). In addition to the intracellular Se content (mass per individual cell), the extracellular Se (dissolved fraction) was also determined directly and simultaneously using the average background from the SC-ICP-MS time-resolved signal. The figures-of-merit of the methods developed have been evaluated by relying on the analysis of the SELM-1 cell-certified reference material, consisting of Se-enriched yeast cells, and certified for its total Se content (intracellular + extracellular Se). All methods successfully determined the Se elemental contents, but an improvement in accuracy and precision was observed for the NP-based methods compared to the reference one. Furthermore, the NP-based methods were found to be less time-consuming, more straightforward, and more user-friendly in terms of calculations. These results open new avenues for calibration in quantitative SC-ICP-MS analysis and call for a fundamental change in the methodology, where the determination of ionic contents is based on the use of ionic standard solutions for calibration, while the determination of elemental contents in discrete micro\/nanoentities, such as cells, should ideally be based on calibration using standard entities, thus avoiding the need to calculate a transport efficiency coefficient.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_258\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588\" title=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588\" target=\"_blank\">https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1021\/acs.analchem.5c01588\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1021\/acs.analchem.5c01588\" target=\"_blank\">doi:https:\/\/doi.org\/10.1021\/acs.analchem.5c01588<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Bolea-Fernandez, Eduardo;  Billimoria, Kharmen;  Rua-Ibarz, Ana;  Aramend\u00eda, Maite;  Menero-Vald\u00e9s, Paula;  Morley, Jack;  Neves, Sara;  S\u00e1nchez-Cachero, Armando;  Goenaga-Infante, Heidi;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('259','tp_links')\" style=\"cursor:pointer;\">A novel particle mass calibration strategy for the quantification of AuNPs in single cancer cells via laser ablation ICP-mass spectrometry. A case study<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_pages\">pp. -, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_259\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D5JA00253B,<br \/>\r\ntitle = {A novel particle mass calibration strategy for the quantification of AuNPs in single cancer cells via laser ablation ICP-mass spectrometry. A case study},<br \/>\r\nauthor = {Antonio Bazo and Eduardo Bolea-Fernandez and Kharmen Billimoria and Ana Rua-Ibarz and Maite Aramend\u00eda and Paula Menero-Vald\u00e9s and Jack Morley and Sara Neves and Armando S\u00e1nchez-Cachero and Heidi Goenaga-Infante and Mart\u00edn Resano},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D5JA00253B},<br \/>\r\ndoi = {10.1039\/D5JA00253B},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\npages = {-},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {Laser ablation ICP-mass spectrometry (LA-ICP-MS) has developed as a powerful tool for elemental quantitative analysis of individual cells, assuring that the content of each cell is analyzed individually. However, this technique is still limited by the difficulties associated with calibration using solid standards. This work proposes a particle mass calibration strategy that is independent of both the properties and thickness of the gelatin films used for calibration, overcoming a significant drawback of previously established methods. The fundamental principle of this strategy relies on the individual ablation of nanoparticles (NPs) of well-characterized size that are embedded in the films, so that their mass can be directly used for calibration without the need to calculate their exact concentration within the gelatin. The performance of the newly developed method was compared to that of the previously reported approaches (ionic and particle number calibration) in terms of linearity and homogeneity between different films prepared from the same gelatin solution. As a case study, the three calibration strategies were used for the quantitative analysis of HeLa cancer cells exposed to AuNPs. In parallel, in-suspension single-cell (SC) ICP-MS Au data were obtained and used as reference for comparison with the three LA-SC-ICP-MS strategies. The results obtained with the novel particle mass approach demonstrated better accuracy and repeatability over three different working sessions, addressing key limitations and providing a robust and reliable method for quantitative LA-SC-ICP-MS analysis. The particle mass method holds promise for quantitative LA-ICP-MS analysis of samples beyond NP-exposed cells, such as biological tissues.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_259\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Laser ablation ICP-mass spectrometry (LA-ICP-MS) has developed as a powerful tool for elemental quantitative analysis of individual cells, assuring that the content of each cell is analyzed individually. However, this technique is still limited by the difficulties associated with calibration using solid standards. This work proposes a particle mass calibration strategy that is independent of both the properties and thickness of the gelatin films used for calibration, overcoming a significant drawback of previously established methods. The fundamental principle of this strategy relies on the individual ablation of nanoparticles (NPs) of well-characterized size that are embedded in the films, so that their mass can be directly used for calibration without the need to calculate their exact concentration within the gelatin. The performance of the newly developed method was compared to that of the previously reported approaches (ionic and particle number calibration) in terms of linearity and homogeneity between different films prepared from the same gelatin solution. As a case study, the three calibration strategies were used for the quantitative analysis of HeLa cancer cells exposed to AuNPs. In parallel, in-suspension single-cell (SC) ICP-MS Au data were obtained and used as reference for comparison with the three LA-SC-ICP-MS strategies. The results obtained with the novel particle mass approach demonstrated better accuracy and repeatability over three different working sessions, addressing key limitations and providing a robust and reliable method for quantitative LA-SC-ICP-MS analysis. The particle mass method holds promise for quantitative LA-ICP-MS analysis of samples beyond NP-exposed cells, such as biological tissues.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_259\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D5JA00253B\" title=\"http:\/\/dx.doi.org\/10.1039\/D5JA00253B\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D5JA00253B<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D5JA00253B\" title=\"DOI de seguimiento:10.1039\/D5JA00253B\" target=\"_blank\">doi:10.1039\/D5JA00253B<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  L\u00f3pez-Villellas, Lori\u00e9n;  Mataloni, Matilde;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Grotti, Marco;  Aramend\u00eda, Maite;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('260','tp_links')\" style=\"cursor:pointer;\">Improving detection and figures of merit in single-particle inductively coupled plasma-mass spectrometry via transient event heights<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Analytica Chimica Acta, <\/span><span class=\"tp_pub_additional_volume\">vol. 1378, <\/span><span class=\"tp_pub_additional_pages\">pp. 344694, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0003-2670<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_260\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{BAZO2025344694,<br \/>\r\ntitle = {Improving detection and figures of merit in single-particle inductively coupled plasma-mass spectrometry via transient event heights},<br \/>\r\nauthor = {Antonio Bazo and Lori\u00e9n L\u00f3pez-Villellas and Matilde Mataloni and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Marco Grotti and Maite Aramend\u00eda and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.aca.2025.344694},<br \/>\r\nissn = {0003-2670},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {Analytica Chimica Acta},<br \/>\r\nvolume = {1378},<br \/>\r\npages = {344694},<br \/>\r\nabstract = {Background <br \/>\r\nSingle-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a powerful method for characterizing micro- and nanoparticulate materials. The technique primarily relies on the linear relationship between the integrated intensities of individual events (peak areas) and the analyte mass, though transit times (peak widths) have also been used for quantitative purposes. This work (1) evaluates the potential of using peak heights as analytical signals in SP-ICP-MS, (2) introduces a new method for determining peak heights, and (3) explores scenarios in which peak height offers added value over the commonly used SP-ICP-MS signals. <br \/>\r\nResults <br \/>\r\nA new method was proposed to estimate peak height values in SP-ICP-MS accurately. The cumulative intensity across consecutive dwell times was modeled using a third-degree polynomial, from which the adjusted peak height was derived. This approach reduces the uncertainty associated with using raw maximum intensity values, yielding NP distributions comparable to those obtained via integrated intensities. The effect of dwell time on peak height was also evaluated. An optimal range (50 \u03bcs\u2013200 \u03bcs) was identified, where a linear relationship was observed between the peak height and the square of the NP diameter. Within this range, peak height showed the lowest bias when characterizing smaller NPs, indicating the potential to improve the limit of quantification (LoQ). Additionally, peak heights proved helpful in determining the limit of detection (LoD) and setting appropriate threshold values for data processing, thereby helping to flag incorrect resultsand addressing a challenge in SP-ICP-MS analysis. <br \/>\r\nSignificance <br \/>\r\nThis is the first study to evaluate peak height as an analytical signal in SP-ICP-MS. The results highlight its advantages in specific applications, such as sizing NPs near the LoD, and in supporting the more reliable use of other signals, such as peak areas, by helping to identify incorrect threshold selection that could lead to biased distributions. Finally, monitoring peak heights allows for a more realistic and assumption-free determination of the LoD.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_260\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Background <br \/>\r\nSingle-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a powerful method for characterizing micro- and nanoparticulate materials. The technique primarily relies on the linear relationship between the integrated intensities of individual events (peak areas) and the analyte mass, though transit times (peak widths) have also been used for quantitative purposes. This work (1) evaluates the potential of using peak heights as analytical signals in SP-ICP-MS, (2) introduces a new method for determining peak heights, and (3) explores scenarios in which peak height offers added value over the commonly used SP-ICP-MS signals. <br \/>\r\nResults <br \/>\r\nA new method was proposed to estimate peak height values in SP-ICP-MS accurately. The cumulative intensity across consecutive dwell times was modeled using a third-degree polynomial, from which the adjusted peak height was derived. This approach reduces the uncertainty associated with using raw maximum intensity values, yielding NP distributions comparable to those obtained via integrated intensities. The effect of dwell time on peak height was also evaluated. An optimal range (50 \u03bcs\u2013200 \u03bcs) was identified, where a linear relationship was observed between the peak height and the square of the NP diameter. Within this range, peak height showed the lowest bias when characterizing smaller NPs, indicating the potential to improve the limit of quantification (LoQ). Additionally, peak heights proved helpful in determining the limit of detection (LoD) and setting appropriate threshold values for data processing, thereby helping to flag incorrect resultsand addressing a challenge in SP-ICP-MS analysis. <br \/>\r\nSignificance <br \/>\r\nThis is the first study to evaluate peak height as an analytical signal in SP-ICP-MS. The results highlight its advantages in specific applications, such as sizing NPs near the LoD, and in supporting the more reliable use of other signals, such as peak areas, by helping to identify incorrect threshold selection that could lead to biased distributions. Finally, monitoring peak heights allows for a more realistic and assumption-free determination of the LoD.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_260\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.aca.2025.344694\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.aca.2025.344694\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.aca.2025.344694<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><h3 class=\"tp_h3\" id=\"tp_h3_2024\">2024<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Aramend\u00eda, Maite;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('240','tp_links')\" style=\"cursor:pointer;\">Intensity- and time-based strategies for micro\/nano-sizing via single-particle ICP-mass spectrometry: A comparative assessment using Au and SiO2 as model particles<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Analytica Chimica Acta, <\/span><span class=\"tp_pub_additional_volume\">vol. 1331, <\/span><span class=\"tp_pub_additional_pages\">pp. 343305, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0003-2670<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_240\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('240','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_240\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('240','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_240\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('240','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_240\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{BAZO2024343305,<br \/>\r\ntitle = {Intensity- and time-based strategies for micro\/nano-sizing via single-particle ICP-mass spectrometry: A comparative assessment using Au and SiO2 as model particles},<br \/>\r\nauthor = {Antonio Bazo and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Maite Aramend\u00eda and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267024011061},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.aca.2024.343305},<br \/>\r\nissn = {0003-2670},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\nurldate = {2024-01-01},<br \/>\r\njournal = {Analytica Chimica Acta},<br \/>\r\nvolume = {1331},<br \/>\r\npages = {343305},<br \/>\r\nabstract = {Background <br \/>\r\nSingle-particle ICP-mass spectrometry (SP-ICP-MS) is a powerful method for micro\/nano-particle (MNP) sizing. Despite the outstanding evolution of the technique in the last decade, most studies still rely on traditional approaches based on (1) the use of integrated intensity as the analytical signal and (2) the calculation of the transport efficiency (TE). However, the increasing availability of MNP standards and advancements in hardware and software have unveiled new venues for MNP sizing, including TE-independent and time-based approaches. This work systematically examines these different methodologies to identify and summarize their strengths and weaknesses, thus helping to determine their preferred application areas. <br \/>\r\nResults <br \/>\r\nDifferent SP-ICP-MS methods for MNP sizing were assessed using AuNPs (20\u201370\u00a0nm) and SiO2MNPs (100\u20131000\u00a0nm). Among TE-dependent approaches, the particle frequency method was characterized by larger uncertainties than the particle size method. The results of the latter were dependent on the appropriate selection of the reference MNP, making the use of multiple reference MNPs recommended. TE-independent methods were based on external (linear and polynomial) calibrations and a relative approach. These methods exhibited the lowest uncertainties of all the strategies evaluated. External calibrations benefited from simpler calculations, but their application could be hindered by a lack of reference MNPs within the desired size range or by the need for interpolations outside the calibration range. Finally, transit time signals are directly proportional to the MNP size rather than its mass. The time-based method demonstrated adequate performance for sizing AuNPs but failed when sizing the largest SiO2MNPs (1000\u00a0nm). <br \/>\r\nSignificance and novelty <br \/>\r\nThis work provides further insights into the application of different SP-ICP-MS methodologies for MNP sizing. Both TE-independent approaches and the monitoring of the transit time as the analytical signal are underused strategies; in this context, a Python script was developed for accurate transit time measurement. After 20 years of development, a quantitative comparison of the different methodologies, including the most novel approaches, is deemed necessary for further growth on solid theoretical ground.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('240','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_240\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Background <br \/>\r\nSingle-particle ICP-mass spectrometry (SP-ICP-MS) is a powerful method for micro\/nano-particle (MNP) sizing. Despite the outstanding evolution of the technique in the last decade, most studies still rely on traditional approaches based on (1) the use of integrated intensity as the analytical signal and (2) the calculation of the transport efficiency (TE). However, the increasing availability of MNP standards and advancements in hardware and software have unveiled new venues for MNP sizing, including TE-independent and time-based approaches. This work systematically examines these different methodologies to identify and summarize their strengths and weaknesses, thus helping to determine their preferred application areas. <br \/>\r\nResults <br \/>\r\nDifferent SP-ICP-MS methods for MNP sizing were assessed using AuNPs (20\u201370\u00a0nm) and SiO2MNPs (100\u20131000\u00a0nm). Among TE-dependent approaches, the particle frequency method was characterized by larger uncertainties than the particle size method. The results of the latter were dependent on the appropriate selection of the reference MNP, making the use of multiple reference MNPs recommended. TE-independent methods were based on external (linear and polynomial) calibrations and a relative approach. These methods exhibited the lowest uncertainties of all the strategies evaluated. External calibrations benefited from simpler calculations, but their application could be hindered by a lack of reference MNPs within the desired size range or by the need for interpolations outside the calibration range. Finally, transit time signals are directly proportional to the MNP size rather than its mass. The time-based method demonstrated adequate performance for sizing AuNPs but failed when sizing the largest SiO2MNPs (1000\u00a0nm). <br \/>\r\nSignificance and novelty <br \/>\r\nThis work provides further insights into the application of different SP-ICP-MS methodologies for MNP sizing. Both TE-independent approaches and the monitoring of the transit time as the analytical signal are underused strategies; in this context, a Python script was developed for accurate transit time measurement. After 20 years of development, a quantitative comparison of the different methodologies, including the most novel approaches, is deemed necessary for further growth on solid theoretical ground.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('240','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_240\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267024011061\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267024011061\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267024011061<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.aca.2024.343305\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.aca.2024.343305\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.aca.2024.343305<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('240','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><\/div><div class=\"tablenav\"><div class=\"tablenav-pages\"><span class=\"displaying-num\">12 registros<\/span> <a class=\"page-numbers button disabled\">&laquo;<\/a> <a class=\"page-numbers button disabled\">&lsaquo;<\/a> 1 de 3 <a href=\"https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?limit=2&amp;tgid=&amp;yr=&amp;type=&amp;usr=&amp;auth=&amp;tsr=#tppubs\" title=\"p\u00e1gina siguiente\" class=\"page-numbers button\">&rsaquo;<\/a> <a href=\"https:\/\/marte.i3a.es\/es\/antonio-bazo-sanchez\/?limit=3&amp;tgid=&amp;yr=&amp;type=&amp;usr=&amp;auth=&amp;tsr=#tppubs\" title=\"\u00faltima p\u00e1gina\" class=\"page-numbers button\">&raquo;<\/a> <\/div><\/div><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":4058,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[239,240],"tags":[],"class_list":["post-3838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phd-student","category-team"],"_links":{"self":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=3838"}],"version-history":[{"count":8,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3838\/revisions"}],"predecessor-version":[{"id":4169,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3838\/revisions\/4169"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/media\/4058"}],"wp:attachment":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=3838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=3838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=3838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}