{"id":3893,"date":"2023-02-27T11:50:26","date_gmt":"2023-02-27T09:50:26","guid":{"rendered":"https:\/\/marte.i3a.es\/?p=3893"},"modified":"2025-06-30T12:27:49","modified_gmt":"2025-06-30T10:27:49","slug":"microsampling-for-biomedical-elemental-analysis-make-every-droplet-count-anadrop","status":"publish","type":"post","link":"https:\/\/marte.i3a.es\/es\/microsampling-for-biomedical-elemental-analysis-make-every-droplet-count-anadrop\/","title":{"rendered":"Micromuestreo para el an\u00e1lisis elemental en el \u00e1mbito biom\u00e9dico: hagamos que cada gota cuente (ANADROP)"},"content":{"rendered":"<p><style>\/*! elementor - v3.5.5 - 03-02-2022 *\/<br \/>\n@media (min-width:768px){.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-icon,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-icon{display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-webkit-box-flex:0;-ms-flex:0 0 auto;flex:0 0 auto}.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-icon-box.elementor-position-top .elementor-icon-box-img{margin:auto}.elementor-widget-icon-box.elementor-vertical-align-top .elementor-icon-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-icon-box.elementor-vertical-align-middle .elementor-icon-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-icon-box.elementor-vertical-align-bottom .elementor-icon-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-icon-box .elementor-icon-box-icon{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-icon-box .elementor-icon-box-wrapper{text-align:center}.elementor-widget-icon-box .elementor-icon-box-title a{color:inherit}.elementor-widget-icon-box .elementor-icon-box-content{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.elementor-widget-icon-box .elementor-icon-box-description{margin:0}<\/style><\/p>\n\n\n<div id=\"pl-gb3893-69d1a460e3f5a\"  class=\"panel-layout wp-block-siteorigin-panels-layout-block\" ><div id=\"pg-gb3893-69d1a460e3f5a-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb3893-69d1a460e3f5a-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb3893-69d1a460e3f5a-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3893-69d1a460e3f5a-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-7a011a7c0fd5-3893 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"\/es\/all-projects\/\">Proyectos<\/a><\/h3>\n<h1 class=\"entry-title\" style=\"text-align: center\"><strong>PID2021-122455NB-I00. Micromuestreo para el an\u00e1lisis elemental en el \u00e1mbito biom\u00e9dico: hagamos que cada gota cuente (ANADROP)<\/strong><\/h1>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb3893-69d1a460e4beb\"  class=\"panel-layout wp-block-siteorigin-panels-layout-block\" ><div id=\"pg-gb3893-69d1a460e4beb-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb3893-69d1a460e4beb-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3893-69d1a460e4beb-0-0-0\" class=\"so-panel widget widget_sow-image panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-image so-widget-sow-image-default-8b5b6f678277-3893\"\n\t\t\t\n\t\t>\n<div class=\"sow-image-container\">\n\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-scaled.jpg\" width=\"2560\" height=\"1440\" srcset=\"https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-scaled.jpg 2560w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-300x169.jpg 300w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-1024x576.jpg 1024w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-768x432.jpg 768w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-1536x864.jpg 1536w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-2048x1152.jpg 2048w, https:\/\/marte.i3a.es\/wp-content\/uploads\/2023\/02\/ANADROP-18x10.jpg 18w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" title=\"ANADROP\" alt=\"\" \t\tclass=\"so-widget-image\"\/>\n\t<\/div>\n\n<\/div><\/div><\/div><div id=\"pgc-gb3893-69d1a460e4beb-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3893-69d1a460e4beb-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"panel-widget-style panel-widget-style-for-gb3893-69d1a460e4beb-0-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<ul>\n<li><strong>Fecha de inicio<\/strong> 01-09-2023<\/li>\n<li><strong>Fecha de finalizaci\u00f3n<\/strong> 31-08-2025<\/li>\n<li><strong>Investigador Principal<\/strong>: Mart\u00edn Resano<\/li>\n<li><strong>Tipo<\/strong>: Proyectos de Generaci\u00f3n de Conocimiento, Ministerio de Ciencia e Innovaci\u00f3n<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-gb3893-69d1a460e4beb-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb3893-69d1a460e4beb-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3893-69d1a460e4beb-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Resumen<\/strong>: Este proyecto persigue el desarrollo de nuevas metodolog\u00edas anal\u00edticas para obtener informaci\u00f3n elemental e isot\u00f3pica a partir de micromuestras, que se pueden obtener de forma m\u00ednimamente invasiva (por ejemplo, dried matrix spots, DMSs), as\u00ed como a partir de micro-entidades (como c\u00e9lulas, nanopart\u00edculas y micro\/nanopl\u00e1sticos), con el fin de obtener informaci\u00f3n individualizada para cada microentidad.<\/p>\n<p>Los m\u00e9todos desarrollados deben ser simples y selectivos, y no requerir ninguna preparaci\u00f3n de la muestra o, en todo caso, una preparaci\u00f3n m\u00ednima (sin digestiones), evitando as\u00ed riesgos de interconversi\u00f3n de especies, de p\u00e9rdidas de analito o de contaminaci\u00f3n y proporcionando mejores l\u00edmites de detecci\u00f3n al tiempo que se garantiza un m\u00ednimo tiempo de an\u00e1lisis.<\/p>\n<p>La principal hip\u00f3tesis del proyecto es que las t\u00e9cnicas de espectrometr\u00eda at\u00f3mica han experimentado mejoras recientes y significativas (por ejemplo, mayor capacidad de adquisici\u00f3n datos de forma ultra-r\u00e1pida, m\u00e1s potencial para hacer frente a solapamientos espectrales y posibilidades para realizar nuevos acoplamientos, como ablaci\u00f3n l\u00e1ser ICP-MS en t\u00e1ndem con LIBS) que, junto con los avances recientes en los dispositivos para generar DMSs de volumen constante y conocido, permiten llevar el micromuestreo en el campo biom\u00e9dico al siguiente nivel.<\/p>\n<p>As\u00ed, en este proyecto se desplegar\u00e1n las t\u00e9cnicas de an\u00e1lisis elemental a nivel de trazas m\u00e1s poderosas (ICP-MS\/MS, LA-ICP-MS\/LIBS y HR CS GFAAS), utilizando instrumentaci\u00f3n de \u00faltima generaci\u00f3n, por lo es factible alcanzar los objetivos espec\u00edficos que se persiguen.<\/p>\n<p>Se han seleccionado y se investigar\u00e1n aplicaciones clave de inter\u00e9s en el campo biom\u00e9dico. El enfoque principal del proyecto, sin embargo, consistir\u00e1 en el desarrollo de nuevos enfoques con una base te\u00f3rica s\u00f3lida que permita la adquisici\u00f3n de la mayor cantidad de informaci\u00f3n posible a partir de cantidades m\u00ednimas de muestra, pero garantizando la capacidad para obtener informaci\u00f3n cuantitativa.<\/p>\n<p>El proyecto se desarrollar\u00e1 en torno a tres objetivos diferentes: i) el desarrollo de estrategias anal\u00edticas novedosas basadas en nuevas configuraciones instrumentales y acoplamientos para el an\u00e1lisis elemental e isot\u00f3pico directo de micromuestras biom\u00e9dicas; ii) el desarrollo de nuevas estrategias anal\u00edticas para el an\u00e1lisis m\u00ednimamente invasivos; y iii) el desarrollo de m\u00e9todos basados en la obtenci\u00f3n de informaci\u00f3n temporal y\/o espacialmente resuelta para el an\u00e1lisis individual de micro\/nano entidades.<\/p>\n<p>Ayuda <strong>PID2021-122455NB-I00 <\/strong>financiada por MCIN\/AEI\/10.13039\/501100011033 y por \u201cFEDER Una manera de hacer Europa.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-gb3893-69d1a460e4beb-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb3893-69d1a460e4beb-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb3893-69d1a460e4beb-2-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-244eb6bef45a-3893\"\n\t\t\t\n\t\t><div class=\"sow-headline-container\">\n\t\t\t\t\t\t\t<h5 class=\"sow-headline\">\n\t\t\t\t\t\tPUBLICACIONES\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n<\/div><\/div><div id=\"panel-gb3893-69d1a460e4beb-2-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\" action=\"\"><a name=\"tppubs\" id=\"tppubs\"><\/a><div class=\"teachpress_filter\"><select class=\"default\" name=\"yr\" id=\"yr\" tabindex=\"2\" onchange=\"teachpress_jumpMenu('parent',this, 'https:\/\/marte.i3a.es\/es\/microsampling-for-biomedical-elemental-analysis-make-every-droplet-count-anadrop\/?')\">\r\n                   <option value=\"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=#tppubs\">Todos los a\u00f1os<\/option>\r\n                   <option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2025#tppubs\" >2025<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2024#tppubs\" >2024<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2023#tppubs\" >2023<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2022#tppubs\" >2022<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2021#tppubs\" >2021<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2020#tppubs\" >2020<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2019#tppubs\" >2019<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2018#tppubs\" >2018<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2017#tppubs\" >2017<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2016#tppubs\" >2016<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2015#tppubs\" >2015<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2014#tppubs\" >2014<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2013#tppubs\" >2013<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2012#tppubs\" >2012<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=2004#tppubs\" >2004<\/option><option value = \"tgid=&amp;type=&amp;auth=&amp;usr=&amp;yr=0000#tppubs\" >0000<\/option>\r\n                <\/select><select class=\"default\" name=\"type\" id=\"type\" tabindex=\"3\" onchange=\"teachpress_jumpMenu('parent',this, 'https:\/\/marte.i3a.es\/es\/microsampling-for-biomedical-elemental-analysis-make-every-droplet-count-anadrop\/?')\">\r\n                   <option value=\"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=#tppubs\">Todas las tipolog\u00edas<\/option>\r\n                   <option value = \"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=article#tppubs\" >Art\u00edculos de revista<\/option><option value = \"tgid=&amp;yr=&amp;auth=&amp;usr=&amp;type=proceedings#tppubs\" >Actas de congresos<\/option>\r\n                <\/select><\/div><input type=\"hidden\" name=\"trp-form-language\" value=\"es\"\/><\/form><div class=\"teachpress_publication_list\"><h3 class=\"tp_h3\" id=\"tp_h3_2025\">2025<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Rua-Ibarz, Ana;  Nakadi, Fl\u00e1vio V.;  Bolea-Fernandez, Eduardo;  Bazo, Antonio;  Battistella, Beatrice;  Matiushkina, Anna;  Resch-Genger, Ute;  Abad, Carlos;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('262','tp_links')\" style=\"cursor:pointer;\">Discrete Entity Analysis via Microwave-Induced Nitrogen Plasma\u2013Mass Spectrometry in Single-Event Mode<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Analytical Chemistry, <\/span><span class=\"tp_pub_additional_volume\">vol. 0, <\/span><span class=\"tp_pub_additional_number\">no 0, <\/span><span class=\"tp_pub_additional_pages\">pp. null, <\/span><span class=\"tp_pub_additional_year\">2025<\/span><span class=\"tp_pub_additional_note\">, (PMID: 41084806)<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_262\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('262','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_262\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{,<br \/>\r\ntitle = {Discrete Entity Analysis via Microwave-Induced Nitrogen Plasma\u2013Mass Spectrometry in Single-Event Mode},<br \/>\r\nauthor = {Ana Rua-Ibarz and Fl\u00e1vio V. Nakadi and Eduardo Bolea-Fernandez and Antonio Bazo and Beatrice Battistella and Anna Matiushkina and Ute Resch-Genger and Carlos Abad and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/doi.org\/10.1021\/acs.analchem.5c04341},<br \/>\r\ndoi = {10.1021\/acs.analchem.5c04341},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-10-14},<br \/>\r\nurldate = {2025-10-14},<br \/>\r\njournal = {Analytical Chemistry},<br \/>\r\nvolume = {0},<br \/>\r\nnumber = {0},<br \/>\r\npages = {null},<br \/>\r\nabstract = {In this work, single-event microwave-induced nitrogen plasma\u2013mass spectrometry (single-event MINP-MS) was evaluated for the first time for the analysis of discrete entities such as nanoparticles, biological cells, and microplastics. Nitrogen (N2) effectively overcomes Ar-based polyatomic interferences, enabling (ultra)trace element determination of Fe and Se using their most abundant isotopes, 56Fe (91.66%) and 80Se (49.82%). Iron oxide nanoparticles (Fe2O3 NPs) ranging from 20 to 70 nm were accurately characterized, with excellent agreement with established sizing techniques, such as transmission electron microscopy (TEM) and dynamic light scattering (DLS). A limit of detection (LoD) of 8.6 ag for Fe\u2500equivalent to an LoDsize of 19 nm for Fe2O3\u2500was achieved, which is significantly lower than recent values reported for high-end quadrupole-based ICP-MS. Selenium nanoparticles (SeNPs) of 150 and 250 nm were also accurately characterized, without the N2-based plasma experiencing issues handling relatively large metallic NPs (linearity, R2 = 0.9994). Se-enriched yeast cells (SELM-1 certified reference material) were successfully analyzed via single-cell MINP-MS using external calibration based on SeNPs and a transport efficiency-independent approach. In addition, 2\u20133 \u03bcm polystyrene (PS) and polytetrafluoroethylene (PTFE) were accurately sized by monitoring 12C+, confirming the method\u2019s suitability for handling micrometer-sized polymeric materials (microplastics). The average duration of individual events (680 \u00b1 160 \u03bcs) suggests that the digestion of individual entities in N2-based plasmas is comparable to that in Ar-based plasmas. These results open new avenues for this instrumentation as an alternative to ICP ionization sources, also in the context of discrete entity analysis.},<br \/>\r\nnote = {PMID: 41084806},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_262\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In this work, single-event microwave-induced nitrogen plasma\u2013mass spectrometry (single-event MINP-MS) was evaluated for the first time for the analysis of discrete entities such as nanoparticles, biological cells, and microplastics. Nitrogen (N2) effectively overcomes Ar-based polyatomic interferences, enabling (ultra)trace element determination of Fe and Se using their most abundant isotopes, 56Fe (91.66%) and 80Se (49.82%). Iron oxide nanoparticles (Fe2O3 NPs) ranging from 20 to 70 nm were accurately characterized, with excellent agreement with established sizing techniques, such as transmission electron microscopy (TEM) and dynamic light scattering (DLS). A limit of detection (LoD) of 8.6 ag for Fe\u2500equivalent to an LoDsize of 19 nm for Fe2O3\u2500was achieved, which is significantly lower than recent values reported for high-end quadrupole-based ICP-MS. Selenium nanoparticles (SeNPs) of 150 and 250 nm were also accurately characterized, without the N2-based plasma experiencing issues handling relatively large metallic NPs (linearity, R2 = 0.9994). Se-enriched yeast cells (SELM-1 certified reference material) were successfully analyzed via single-cell MINP-MS using external calibration based on SeNPs and a transport efficiency-independent approach. In addition, 2\u20133 \u03bcm polystyrene (PS) and polytetrafluoroethylene (PTFE) were accurately sized by monitoring 12C+, confirming the method\u2019s suitability for handling micrometer-sized polymeric materials (microplastics). The average duration of individual events (680 \u00b1 160 \u03bcs) suggests that the digestion of individual entities in N2-based plasmas is comparable to that in Ar-based plasmas. These results open new avenues for this instrumentation as an alternative to ICP ionization sources, also in the context of discrete entity analysis.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_262\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/doi.org\/10.1021\/acs.analchem.5c04341\" title=\"https:\/\/doi.org\/10.1021\/acs.analchem.5c04341\" target=\"_blank\">https:\/\/doi.org\/10.1021\/acs.analchem.5c04341<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1021\/acs.analchem.5c04341\" title=\"DOI de seguimiento:10.1021\/acs.analchem.5c04341\" target=\"_blank\">doi:10.1021\/acs.analchem.5c04341<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('262','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Aramend\u00eda, Maite;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('258','tp_links')\" style=\"cursor:pointer;\">Ions with Ions, Entities with Entities: A Proof-of-Concept Study Using the SELM-1 Yeast Certified Reference Material for Intra- and Extracellular Se Quantification via Single-Cell ICP-Mass Spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Anal. Chem., <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 1520-6882<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_258\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('258','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_258\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Ions with Ions, Entities with Entities: A Proof-of-Concept Study Using the SELM-1 Yeast Certified Reference Material for Intra- and Extracellular Se Quantification via Single-Cell ICP-Mass Spectrometry},<br \/>\r\nauthor = {Antonio Bazo and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Maite Aramend\u00eda and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1021\/acs.analchem.5c01588},<br \/>\r\nissn = {1520-6882},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-06-07},<br \/>\r\nurldate = {2025-06-07},<br \/>\r\njournal = {Anal. Chem.},<br \/>\r\nabstract = {In this work, two novel nanoparticle (NP)-based calibration strategies, external calibration and a relative method, have been explored for single-cell ICP-mass spectrometry (SC-ICP-MS) analysis. The fundamental principle of these methods is to rely on individual entities (well-characterized NPs of the target analyte) for calibration rather than on ionic standard solutions. The performance of the NP-based calibration approaches has been compared to that of the reference method (particle size with AuNP standards). In addition to the intracellular Se content (mass per individual cell), the extracellular Se (dissolved fraction) was also determined directly and simultaneously using the average background from the SC-ICP-MS time-resolved signal. The figures-of-merit of the methods developed have been evaluated by relying on the analysis of the SELM-1 cell-certified reference material, consisting of Se-enriched yeast cells, and certified for its total Se content (intracellular + extracellular Se). All methods successfully determined the Se elemental contents, but an improvement in accuracy and precision was observed for the NP-based methods compared to the reference one. Furthermore, the NP-based methods were found to be less time-consuming, more straightforward, and more user-friendly in terms of calculations. These results open new avenues for calibration in quantitative SC-ICP-MS analysis and call for a fundamental change in the methodology, where the determination of ionic contents is based on the use of ionic standard solutions for calibration, while the determination of elemental contents in discrete micro\/nanoentities, such as cells, should ideally be based on calibration using standard entities, thus avoiding the need to calculate a transport efficiency coefficient.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_258\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In this work, two novel nanoparticle (NP)-based calibration strategies, external calibration and a relative method, have been explored for single-cell ICP-mass spectrometry (SC-ICP-MS) analysis. The fundamental principle of these methods is to rely on individual entities (well-characterized NPs of the target analyte) for calibration rather than on ionic standard solutions. The performance of the NP-based calibration approaches has been compared to that of the reference method (particle size with AuNP standards). In addition to the intracellular Se content (mass per individual cell), the extracellular Se (dissolved fraction) was also determined directly and simultaneously using the average background from the SC-ICP-MS time-resolved signal. The figures-of-merit of the methods developed have been evaluated by relying on the analysis of the SELM-1 cell-certified reference material, consisting of Se-enriched yeast cells, and certified for its total Se content (intracellular + extracellular Se). All methods successfully determined the Se elemental contents, but an improvement in accuracy and precision was observed for the NP-based methods compared to the reference one. Furthermore, the NP-based methods were found to be less time-consuming, more straightforward, and more user-friendly in terms of calculations. These results open new avenues for calibration in quantitative SC-ICP-MS analysis and call for a fundamental change in the methodology, where the determination of ionic contents is based on the use of ionic standard solutions for calibration, while the determination of elemental contents in discrete micro\/nanoentities, such as cells, should ideally be based on calibration using standard entities, thus avoiding the need to calculate a transport efficiency coefficient.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_258\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588\" title=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588\" target=\"_blank\">https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.5c01588<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1021\/acs.analchem.5c01588\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1021\/acs.analchem.5c01588\" target=\"_blank\">doi:https:\/\/doi.org\/10.1021\/acs.analchem.5c01588<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('258','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Rodler-R\u00f8rbo, Alexandra;  Baragona, Anthony J.;  Verbeemen, Eliah J.;  S\u00f8rensen, Lasse Vilien;  \u00c7akmako\u011flu, Berk;  Helvaci, Cahit;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Vanhaecke, Frank;  Becker, Hilary;  Artioli, Gilberto;  Zabrana, Lilli;  Debaille, Vinciane;  Mattielli, Nadine;  Goderis, Steven;  Claeys, Philippe<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('251','tp_links')\" style=\"cursor:pointer;\">Cinnabar for Roman Ephesus: Material quality, processing and provenance<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Journal of Archaeological Science, <\/span><span class=\"tp_pub_additional_volume\">vol. 173, <\/span><span class=\"tp_pub_additional_pages\">pp. 106122, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0305-4403<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_251\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('251','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_251\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('251','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_251\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('251','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_251\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{RODLERRORBO2025106122,<br \/>\r\ntitle = {Cinnabar for Roman Ephesus: Material quality, processing and provenance},<br \/>\r\nauthor = {Alexandra Rodler-R\u00f8rbo and Anthony J. Baragona and Eliah J. Verbeemen and Lasse Vilien S\u00f8rensen and Berk \u00c7akmako\u011flu and Cahit Helvaci and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Frank Vanhaecke and Hilary Becker and Gilberto Artioli and Lilli Zabrana and Vinciane Debaille and Nadine Mattielli and Steven Goderis and Philippe Claeys},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305440324001900},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.jas.2024.106122},<br \/>\r\nissn = {0305-4403},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {Journal of Archaeological Science},<br \/>\r\nvolume = {173},<br \/>\r\npages = {106122},<br \/>\r\nabstract = {Ephesus was an important harbor city that flourished during the Roman period and ancient texts mention Almad\u00e9n in Spain and the Cilbian fields of Ephesus as important cinnabar sources in antiquity. This work investigates whether imported cinnabar was used and whether this could be related to changes in painting activities over time. Microscopic analysis indicates a consistent preparation of cinnabar, hinting at a uniform source material quality or processing technique. However, the use of cinnabar varies among the architectural structures studied, indicating a plurality of painting techniques. A few of the analyzed cinnabar samples overlap with Turkish- and Balkan reference Pb isotope ratios; three samples from tabernas, however, deviate from this. The Hg isotope ratios reveal that cinnabar from carbonate-hosted deposits was likely used, and that processing of cinnabar included heating as suggested by ancient texts. Most notably, a correlation exists between the geochemical data and the painting technique \u2013 shifts in sourcing and cinnabar usage are potentially assignable to building chronology and\/or usage. Through the lens of material provenance and processing, Ephesian cinnabar brings the organization of pigment trade into focus.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('251','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_251\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Ephesus was an important harbor city that flourished during the Roman period and ancient texts mention Almad\u00e9n in Spain and the Cilbian fields of Ephesus as important cinnabar sources in antiquity. This work investigates whether imported cinnabar was used and whether this could be related to changes in painting activities over time. Microscopic analysis indicates a consistent preparation of cinnabar, hinting at a uniform source material quality or processing technique. However, the use of cinnabar varies among the architectural structures studied, indicating a plurality of painting techniques. A few of the analyzed cinnabar samples overlap with Turkish- and Balkan reference Pb isotope ratios; three samples from tabernas, however, deviate from this. The Hg isotope ratios reveal that cinnabar from carbonate-hosted deposits was likely used, and that processing of cinnabar included heating as suggested by ancient texts. Most notably, a correlation exists between the geochemical data and the painting technique \u2013 shifts in sourcing and cinnabar usage are potentially assignable to building chronology and\/or usage. Through the lens of material provenance and processing, Ephesian cinnabar brings the organization of pigment trade into focus.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('251','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_251\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305440324001900\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305440324001900\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305440324001900<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.jas.2024.106122\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.jas.2024.106122\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.jas.2024.106122<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('251','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Nakadi, Fl\u00e1vio V.;  Garcia-Garcia, Alicia;  Rua-Ibarz, Ana;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('254','tp_links')\" style=\"cursor:pointer;\">LAMIS in the gas phase: A new approach for obtaining Ca elemental and isotopic information via CaF molecule formation<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Talanta, <\/span><span class=\"tp_pub_additional_volume\">vol. 292, <\/span><span class=\"tp_pub_additional_pages\">pp. 127920, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0039-9140<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_254\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('254','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_254\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('254','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_254\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('254','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_254\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{NAKADI2025127920,<br \/>\r\ntitle = {LAMIS in the gas phase: A new approach for obtaining Ca elemental and isotopic information via CaF molecule formation},<br \/>\r\nauthor = {Fl\u00e1vio V. Nakadi and Alicia Garcia-Garcia and Ana Rua-Ibarz and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914025004102},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.talanta.2025.127920},<br \/>\r\nissn = {0039-9140},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {Talanta},<br \/>\r\nvolume = {292},<br \/>\r\npages = {127920},<br \/>\r\nabstract = {This work introduces a novel method for generating the calcium monofluoride (CaF) diatomic molecule by adding the molecule-forming reagent in the gaseous phase (a methyl fluoride-argon mixture), in order to perform laser-induced breakdown spectroscopy (LIBS) and laser ablation molecular isotopic spectrometry (LAMIS) measurements. By optimizing the instrumental parameters, CaF molecule formation was successfully achieved within the plasma plume, upon ablation of dried liquid samples. The isotopic shift for the X2\u03a3\u2192A2\u03a0 (0,1) CaF vibronic transition at 583.0\u00a0nm was calculated to be 292.3 pm. The method proved capable of providing quantitative information for determining calcium concentrations in real samples, such as tap water and skimmed milk, using internal standardization (with Sr as internal standard; limit of detection, LOD, 20\u00a0mg\u00a0L\u22121) and isotope dilution (which can be applied from 400\u00a0mg\u00a0L\u22121on), respectively. Partial least squares regression (PLS) analysis was employed to enhance the quality of the isotopic data. The Ca concentration found in the tap water was 47\u00a0\u00b1\u00a016\u00a0mg\u00a0L\u22121 (reference flame atomic absorption spectrometry, FAAS, value: 59\u00a0\u00b1\u00a00.2\u00a0mg\u00a0L\u22121), and 1100\u00a0\u00b1\u00a0140\u00a0mg\u00a0L\u22121 for the skimmed milk (reference FAAS value: 1240\u00a0\u00b1\u00a0120\u00a0mg\u00a0L\u22121). No significant difference between LIBS and FAAS results could be established using a t-test at the 95% confidence level. Overall, this novel approach allows for the determination of calcium in terms of both the elemental concentration and the isotopic composition, thus broadening the applicability of LIBS (e.g., for tracer experiments, besides the already mentioned application of isotope dilution).},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('254','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_254\" style=\"display:none;\"><div class=\"tp_abstract_entry\">This work introduces a novel method for generating the calcium monofluoride (CaF) diatomic molecule by adding the molecule-forming reagent in the gaseous phase (a methyl fluoride-argon mixture), in order to perform laser-induced breakdown spectroscopy (LIBS) and laser ablation molecular isotopic spectrometry (LAMIS) measurements. By optimizing the instrumental parameters, CaF molecule formation was successfully achieved within the plasma plume, upon ablation of dried liquid samples. The isotopic shift for the X2\u03a3\u2192A2\u03a0 (0,1) CaF vibronic transition at 583.0\u00a0nm was calculated to be 292.3 pm. The method proved capable of providing quantitative information for determining calcium concentrations in real samples, such as tap water and skimmed milk, using internal standardization (with Sr as internal standard; limit of detection, LOD, 20\u00a0mg\u00a0L\u22121) and isotope dilution (which can be applied from 400\u00a0mg\u00a0L\u22121on), respectively. Partial least squares regression (PLS) analysis was employed to enhance the quality of the isotopic data. The Ca concentration found in the tap water was 47\u00a0\u00b1\u00a016\u00a0mg\u00a0L\u22121 (reference flame atomic absorption spectrometry, FAAS, value: 59\u00a0\u00b1\u00a00.2\u00a0mg\u00a0L\u22121), and 1100\u00a0\u00b1\u00a0140\u00a0mg\u00a0L\u22121 for the skimmed milk (reference FAAS value: 1240\u00a0\u00b1\u00a0120\u00a0mg\u00a0L\u22121). No significant difference between LIBS and FAAS results could be established using a t-test at the 95% confidence level. Overall, this novel approach allows for the determination of calcium in terms of both the elemental concentration and the isotopic composition, thus broadening the applicability of LIBS (e.g., for tracer experiments, besides the already mentioned application of isotope dilution).<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('254','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_254\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914025004102\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914025004102\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914025004102<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.talanta.2025.127920\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.talanta.2025.127920\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.talanta.2025.127920<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('254','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Sullivan, Kaj V.;  Moser, Katharina;  Costas-Rodr\u00edguez, Marta;  Bolea-Fernandez, Eduardo;  Vanhaecke, Frank<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('255','tp_links')\" style=\"cursor:pointer;\">High-precision Cu isotopic analysis of human dietary Cu sources via multi-collector ICP-mass spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Food Chemistry, <\/span><span class=\"tp_pub_additional_volume\">vol. 470, <\/span><span class=\"tp_pub_additional_pages\">pp. 142673, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0308-8146<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_255\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('255','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_255\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('255','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_255\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('255','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_255\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{SULLIVAN2025142673,<br \/>\r\ntitle = {High-precision Cu isotopic analysis of human dietary Cu sources via multi-collector ICP-mass spectrometry},<br \/>\r\nauthor = {Kaj V. Sullivan and Katharina Moser and Marta Costas-Rodr\u00edguez and Eduardo Bolea-Fernandez and Frank Vanhaecke},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0308814624043231},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.foodchem.2024.142673},<br \/>\r\nissn = {0308-8146},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {Food Chemistry},<br \/>\r\nvolume = {470},<br \/>\r\npages = {142673},<br \/>\r\nabstract = {The disruption of Cu homeostasis is associated with the pathogenesis of many diseases and can result in alterations in Cu isotope fractionation. Changes in the Cu isotope ratio (65Cu\/63Cu) of body fluids and tissues have been observed in liver disorders, cancers, and other diseases, displaying diagnostic\/prognostic potential. However, it is not entirely clear whether certain physiological or lifestyle factors may also influence the bodily Cu isotopic composition, potentially obfuscating the signature of the pathology. To ascertain whether differences exist between food products, the Cu isotopic composition of 29 significant dietary Cu sources has been determined for the first time. The general enrichment of Cu and its heavy isotope, 65Cu, in legumes, nuts, and seeds (major Cu sources in plant-based diets) was revealed, suggesting that individuals with plant-based diets may have a bodily Cu isotopic composition offset from that of individuals with omnivorous diets, thus requiring controlling for in study design.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('255','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_255\" style=\"display:none;\"><div class=\"tp_abstract_entry\">The disruption of Cu homeostasis is associated with the pathogenesis of many diseases and can result in alterations in Cu isotope fractionation. Changes in the Cu isotope ratio (65Cu\/63Cu) of body fluids and tissues have been observed in liver disorders, cancers, and other diseases, displaying diagnostic\/prognostic potential. However, it is not entirely clear whether certain physiological or lifestyle factors may also influence the bodily Cu isotopic composition, potentially obfuscating the signature of the pathology. To ascertain whether differences exist between food products, the Cu isotopic composition of 29 significant dietary Cu sources has been determined for the first time. The general enrichment of Cu and its heavy isotope, 65Cu, in legumes, nuts, and seeds (major Cu sources in plant-based diets) was revealed, suggesting that individuals with plant-based diets may have a bodily Cu isotopic composition offset from that of individuals with omnivorous diets, thus requiring controlling for in study design.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('255','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_255\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0308814624043231\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0308814624043231\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0308814624043231<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.foodchem.2024.142673\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.foodchem.2024.142673\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.foodchem.2024.142673<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('255','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Bolea-Fernandez, Eduardo;  Billimoria, Kharmen;  Rua-Ibarz, Ana;  Aramend\u00eda, Maite;  Menero-Vald\u00e9s, Paula;  Morley, Jack;  Neves, Sara;  S\u00e1nchez-Cachero, Armando;  Goenaga-Infante, Heidi;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('259','tp_links')\" style=\"cursor:pointer;\">A novel particle mass calibration strategy for the quantification of AuNPs in single cancer cells via laser ablation ICP-mass spectrometry. A case study<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_pages\">pp. -, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_259\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('259','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_259\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D5JA00253B,<br \/>\r\ntitle = {A novel particle mass calibration strategy for the quantification of AuNPs in single cancer cells via laser ablation ICP-mass spectrometry. A case study},<br \/>\r\nauthor = {Antonio Bazo and Eduardo Bolea-Fernandez and Kharmen Billimoria and Ana Rua-Ibarz and Maite Aramend\u00eda and Paula Menero-Vald\u00e9s and Jack Morley and Sara Neves and Armando S\u00e1nchez-Cachero and Heidi Goenaga-Infante and Mart\u00edn Resano},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D5JA00253B},<br \/>\r\ndoi = {10.1039\/D5JA00253B},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\npages = {-},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {Laser ablation ICP-mass spectrometry (LA-ICP-MS) has developed as a powerful tool for elemental quantitative analysis of individual cells, assuring that the content of each cell is analyzed individually. However, this technique is still limited by the difficulties associated with calibration using solid standards. This work proposes a particle mass calibration strategy that is independent of both the properties and thickness of the gelatin films used for calibration, overcoming a significant drawback of previously established methods. The fundamental principle of this strategy relies on the individual ablation of nanoparticles (NPs) of well-characterized size that are embedded in the films, so that their mass can be directly used for calibration without the need to calculate their exact concentration within the gelatin. The performance of the newly developed method was compared to that of the previously reported approaches (ionic and particle number calibration) in terms of linearity and homogeneity between different films prepared from the same gelatin solution. As a case study, the three calibration strategies were used for the quantitative analysis of HeLa cancer cells exposed to AuNPs. In parallel, in-suspension single-cell (SC) ICP-MS Au data were obtained and used as reference for comparison with the three LA-SC-ICP-MS strategies. The results obtained with the novel particle mass approach demonstrated better accuracy and repeatability over three different working sessions, addressing key limitations and providing a robust and reliable method for quantitative LA-SC-ICP-MS analysis. The particle mass method holds promise for quantitative LA-ICP-MS analysis of samples beyond NP-exposed cells, such as biological tissues.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_259\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Laser ablation ICP-mass spectrometry (LA-ICP-MS) has developed as a powerful tool for elemental quantitative analysis of individual cells, assuring that the content of each cell is analyzed individually. However, this technique is still limited by the difficulties associated with calibration using solid standards. This work proposes a particle mass calibration strategy that is independent of both the properties and thickness of the gelatin films used for calibration, overcoming a significant drawback of previously established methods. The fundamental principle of this strategy relies on the individual ablation of nanoparticles (NPs) of well-characterized size that are embedded in the films, so that their mass can be directly used for calibration without the need to calculate their exact concentration within the gelatin. The performance of the newly developed method was compared to that of the previously reported approaches (ionic and particle number calibration) in terms of linearity and homogeneity between different films prepared from the same gelatin solution. As a case study, the three calibration strategies were used for the quantitative analysis of HeLa cancer cells exposed to AuNPs. In parallel, in-suspension single-cell (SC) ICP-MS Au data were obtained and used as reference for comparison with the three LA-SC-ICP-MS strategies. The results obtained with the novel particle mass approach demonstrated better accuracy and repeatability over three different working sessions, addressing key limitations and providing a robust and reliable method for quantitative LA-SC-ICP-MS analysis. The particle mass method holds promise for quantitative LA-ICP-MS analysis of samples beyond NP-exposed cells, such as biological tissues.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_259\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D5JA00253B\" title=\"http:\/\/dx.doi.org\/10.1039\/D5JA00253B\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D5JA00253B<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D5JA00253B\" title=\"DOI de seguimiento:10.1039\/D5JA00253B\" target=\"_blank\">doi:10.1039\/D5JA00253B<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('259','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  L\u00f3pez-Villellas, Lori\u00e9n;  Mataloni, Matilde;  Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Grotti, Marco;  Aramend\u00eda, Maite;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('260','tp_links')\" style=\"cursor:pointer;\">Improving detection and figures of merit in single-particle inductively coupled plasma-mass spectrometry via transient event heights<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Analytica Chimica Acta, <\/span><span class=\"tp_pub_additional_volume\">vol. 1378, <\/span><span class=\"tp_pub_additional_pages\">pp. 344694, <\/span><span class=\"tp_pub_additional_year\">2025<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0003-2670<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_260\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('260','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_260\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{BAZO2025344694,<br \/>\r\ntitle = {Improving detection and figures of merit in single-particle inductively coupled plasma-mass spectrometry via transient event heights},<br \/>\r\nauthor = {Antonio Bazo and Lori\u00e9n L\u00f3pez-Villellas and Matilde Mataloni and Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Marco Grotti and Maite Aramend\u00eda and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.aca.2025.344694},<br \/>\r\nissn = {0003-2670},<br \/>\r\nyear  = {2025},<br \/>\r\ndate = {2025-01-01},<br \/>\r\nurldate = {2025-01-01},<br \/>\r\njournal = {Analytica Chimica Acta},<br \/>\r\nvolume = {1378},<br \/>\r\npages = {344694},<br \/>\r\nabstract = {Background <br \/>\r\nSingle-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a powerful method for characterizing micro- and nanoparticulate materials. The technique primarily relies on the linear relationship between the integrated intensities of individual events (peak areas) and the analyte mass, though transit times (peak widths) have also been used for quantitative purposes. This work (1) evaluates the potential of using peak heights as analytical signals in SP-ICP-MS, (2) introduces a new method for determining peak heights, and (3) explores scenarios in which peak height offers added value over the commonly used SP-ICP-MS signals. <br \/>\r\nResults <br \/>\r\nA new method was proposed to estimate peak height values in SP-ICP-MS accurately. The cumulative intensity across consecutive dwell times was modeled using a third-degree polynomial, from which the adjusted peak height was derived. This approach reduces the uncertainty associated with using raw maximum intensity values, yielding NP distributions comparable to those obtained via integrated intensities. The effect of dwell time on peak height was also evaluated. An optimal range (50 \u03bcs\u2013200 \u03bcs) was identified, where a linear relationship was observed between the peak height and the square of the NP diameter. Within this range, peak height showed the lowest bias when characterizing smaller NPs, indicating the potential to improve the limit of quantification (LoQ). Additionally, peak heights proved helpful in determining the limit of detection (LoD) and setting appropriate threshold values for data processing, thereby helping to flag incorrect resultsand addressing a challenge in SP-ICP-MS analysis. <br \/>\r\nSignificance <br \/>\r\nThis is the first study to evaluate peak height as an analytical signal in SP-ICP-MS. The results highlight its advantages in specific applications, such as sizing NPs near the LoD, and in supporting the more reliable use of other signals, such as peak areas, by helping to identify incorrect threshold selection that could lead to biased distributions. Finally, monitoring peak heights allows for a more realistic and assumption-free determination of the LoD.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_260\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Background <br \/>\r\nSingle-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a powerful method for characterizing micro- and nanoparticulate materials. The technique primarily relies on the linear relationship between the integrated intensities of individual events (peak areas) and the analyte mass, though transit times (peak widths) have also been used for quantitative purposes. This work (1) evaluates the potential of using peak heights as analytical signals in SP-ICP-MS, (2) introduces a new method for determining peak heights, and (3) explores scenarios in which peak height offers added value over the commonly used SP-ICP-MS signals. <br \/>\r\nResults <br \/>\r\nA new method was proposed to estimate peak height values in SP-ICP-MS accurately. The cumulative intensity across consecutive dwell times was modeled using a third-degree polynomial, from which the adjusted peak height was derived. This approach reduces the uncertainty associated with using raw maximum intensity values, yielding NP distributions comparable to those obtained via integrated intensities. The effect of dwell time on peak height was also evaluated. An optimal range (50 \u03bcs\u2013200 \u03bcs) was identified, where a linear relationship was observed between the peak height and the square of the NP diameter. Within this range, peak height showed the lowest bias when characterizing smaller NPs, indicating the potential to improve the limit of quantification (LoQ). Additionally, peak heights proved helpful in determining the limit of detection (LoD) and setting appropriate threshold values for data processing, thereby helping to flag incorrect resultsand addressing a challenge in SP-ICP-MS analysis. <br \/>\r\nSignificance <br \/>\r\nThis is the first study to evaluate peak height as an analytical signal in SP-ICP-MS. The results highlight its advantages in specific applications, such as sizing NPs near the LoD, and in supporting the more reliable use of other signals, such as peak areas, by helping to identify incorrect threshold selection that could lead to biased distributions. Finally, monitoring peak heights allows for a more realistic and assumption-free determination of the LoD.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_260\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003267025010888<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.aca.2025.344694\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.aca.2025.344694\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.aca.2025.344694<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('260','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><h3 class=\"tp_h3\" id=\"tp_h3_2024\">2024<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Aramend\u00eda, Maite;  Souza, Andr\u00e9 L. M.;  Nakadi, Fl\u00e1vio V.;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('231','tp_links')\" style=\"cursor:pointer;\">Boron elemental and isotopic determination via the BF diatomic molecule using high-resolution continuum source graphite furnace molecular absorption spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_volume\">vol. 39, <\/span><span class=\"tp_pub_additional_pages\">pp. 767-779, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_231\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('231','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_231\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('231','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_231\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('231','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_231\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D3JA00420A,<br \/>\r\ntitle = {Boron elemental and isotopic determination via the BF diatomic molecule using high-resolution continuum source graphite furnace molecular absorption spectrometry},<br \/>\r\nauthor = {Maite Aramend\u00eda and Andr\u00e9 L. M. Souza and Fl\u00e1vio V. Nakadi and Mart\u00edn Resano},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D3JA00420A},<br \/>\r\ndoi = {10.1039\/D3JA00420A},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\nurldate = {2024-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\nvolume = {39},<br \/>\r\npages = {767-779},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {Boron trace determination in biological materials is needed in different fields of application. Direct B determination by means of Graphite Furnace Atomic Absorption Spectrometry (SS-GFAAS) has been used in the past for this purpose, offering good detection limits hardly achievable by other techniques. However, such methods require the use of high atomization temperatures combined with large integration times to promote B atomization, which dramatically reduces the lifetime of the instrument&#039;s graphite parts. In this work, a new perspective for B determination by means of Graphite Furnace Molecular Absorption Spectrometry (GFMAS) is proposed. B was detected as the diatomic molecule BF (boron monofluoride), deploying a gas phase reaction with CH3F as fluorinating agent. Based on this strategy, a method for the direct determination of B in two biological certified reference materials (NIST SRM 1570a spinach leaves and NIST SRM 1573a tomato leaves) has been developed, providing similar detection capabilities to the GFAAS method (LOD of 0.24 ng) but requiring much milder furnace conditions. Moreover, the appearance of memory effects, very common in GFAAS methods, is also avoided with this method. Straightforward calibration with aqueous standard solutions was also found to be possible. To this end, a mixture of W (permanent), citric acid, and Ca as chemical modifiers was found to be essential for obtaining a reproducible and sufficiently sensitive signal for boron solutions, comparable to the signals obtained for the solid samples. With this method, accurate results were obtained for the direct analysis of both certified reference materials, provided that spectral interferences from the PO molecule were properly corrected. Precision values in the range of 15% RSD, as typically reported for direct solid sampling GFAAS, were found. Finally, and as an additional advantage of the GFMAS method, a large isotopic shift in the absorbance of the 10BF and 11BF molecules can be accurately monitored at a secondary transition for the BF molecule. This offers novel analytical possibilities for the method, which are also explored in this study. In this regard, control of the B concentration was found to be critical for obtaining accurate and precise isotope ratios for this element.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('231','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_231\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Boron trace determination in biological materials is needed in different fields of application. Direct B determination by means of Graphite Furnace Atomic Absorption Spectrometry (SS-GFAAS) has been used in the past for this purpose, offering good detection limits hardly achievable by other techniques. However, such methods require the use of high atomization temperatures combined with large integration times to promote B atomization, which dramatically reduces the lifetime of the instrument&#039;s graphite parts. In this work, a new perspective for B determination by means of Graphite Furnace Molecular Absorption Spectrometry (GFMAS) is proposed. B was detected as the diatomic molecule BF (boron monofluoride), deploying a gas phase reaction with CH3F as fluorinating agent. Based on this strategy, a method for the direct determination of B in two biological certified reference materials (NIST SRM 1570a spinach leaves and NIST SRM 1573a tomato leaves) has been developed, providing similar detection capabilities to the GFAAS method (LOD of 0.24 ng) but requiring much milder furnace conditions. Moreover, the appearance of memory effects, very common in GFAAS methods, is also avoided with this method. Straightforward calibration with aqueous standard solutions was also found to be possible. To this end, a mixture of W (permanent), citric acid, and Ca as chemical modifiers was found to be essential for obtaining a reproducible and sufficiently sensitive signal for boron solutions, comparable to the signals obtained for the solid samples. With this method, accurate results were obtained for the direct analysis of both certified reference materials, provided that spectral interferences from the PO molecule were properly corrected. Precision values in the range of 15% RSD, as typically reported for direct solid sampling GFAAS, were found. Finally, and as an additional advantage of the GFMAS method, a large isotopic shift in the absorbance of the 10BF and 11BF molecules can be accurately monitored at a secondary transition for the BF molecule. This offers novel analytical possibilities for the method, which are also explored in this study. In this regard, control of the B concentration was found to be critical for obtaining accurate and precise isotope ratios for this element.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('231','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_231\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D3JA00420A\" title=\"http:\/\/dx.doi.org\/10.1039\/D3JA00420A\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D3JA00420A<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D3JA00420A\" title=\"DOI de seguimiento:10.1039\/D3JA00420A\" target=\"_blank\">doi:10.1039\/D3JA00420A<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('231','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Su\u00e1rez-Criado, Laura;  Bolea-Fernandez, Eduardo;  Abou-Zeid, Lana;  Vandermeiren, Mathias;  Rodr\u00edguez-Gonz\u00e1lez, Pablo;  Alonso, Jose Ignacio Garcia;  Vanhaecke, Frank<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('236','tp_links')\" style=\"cursor:pointer;\">Extending the application range of Hg isotopic analysis to sub-\u03bcg L\u22121 levels using cold vapor generation multi-collector inductively coupled plasma-mass spectrometry with 1013 ohm Faraday cup amplifiers<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_volume\">vol. 39, <\/span><span class=\"tp_pub_additional_issue\">iss. 2, <\/span><span class=\"tp_pub_additional_pages\">pp. 592-600, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_236\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('236','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_236\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('236','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_236\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('236','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_236\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D3JA00414G,<br \/>\r\ntitle = {Extending the application range of Hg isotopic analysis to sub-\u03bcg L\u22121 levels using cold vapor generation multi-collector inductively coupled plasma-mass spectrometry with 1013 ohm Faraday cup amplifiers},<br \/>\r\nauthor = {Laura Su\u00e1rez-Criado and Eduardo Bolea-Fernandez and Lana Abou-Zeid and Mathias Vandermeiren and Pablo Rodr\u00edguez-Gonz\u00e1lez and Jose Ignacio Garcia Alonso and Frank Vanhaecke},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D3JA00414G},<br \/>\r\ndoi = {10.1039\/D3JA00414G},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\nurldate = {2024-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\nvolume = {39},<br \/>\r\nissue = {2},<br \/>\r\npages = {592-600},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {High-precision determination of the isotopic composition of mercury (Hg) is of paramount importance for unraveling its biogeochemical cycle and for identifying the origin of Hg in environmental compartments. Cold vapor generation multi-collector inductively coupled plasma-mass spectrometry (CVG-MC-ICP-MS) is the standard approach for such application. Cold vapor generation provides a high Hg introduction efficiency into the ICP, while chromatographic Hg isolation is not required as a result of the selective reaction between Hg2+ and SnCl2. For environmental or biota samples with low Hg concentrations, however, this approach still presents challenges and reliable measurements typically require a Hg concentration \u22651 \u03bcg L\u22121 in the solution analyzed. Recent improvements of MC-ICP-MS instrumentation, including the introduction of the so-called Jet interface and 1013 \u03a9 Faraday cup amplifiers, enhance the signal-to-noise ratio. In this study, it was investigated to what extent this allows Hg isotopic analysis at lower concentration. Performance in Hg isotopic analysis was compared using two different sets of cones (standard vs. Jet), two plasma conditions (wet vs. dry) and two amplifier types (1011 \u03a9 vs. 1013 \u03a9). Satisfactory accuracy and precision were achieved at a Hg concentration down to 0.1 \u03bcg L\u22121 in the solution measured when using Jet cones, dry plasma conditions, and the four available 1013 \u03a9 amplifiers. The uncertainty expressed as 2SD for the \u03b4202Hg values measured for the in-house standard solution was \u00b10.2\u2030 at 0.25 \u03bcg Hg L\u22121 and \u00b1 0.3\u2030 at 0.1 \u03bcg Hg L\u22121. The method was subsequently applied to the analysis of real surface water samples contaminated with toxic metals.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('236','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_236\" style=\"display:none;\"><div class=\"tp_abstract_entry\">High-precision determination of the isotopic composition of mercury (Hg) is of paramount importance for unraveling its biogeochemical cycle and for identifying the origin of Hg in environmental compartments. Cold vapor generation multi-collector inductively coupled plasma-mass spectrometry (CVG-MC-ICP-MS) is the standard approach for such application. Cold vapor generation provides a high Hg introduction efficiency into the ICP, while chromatographic Hg isolation is not required as a result of the selective reaction between Hg2+ and SnCl2. For environmental or biota samples with low Hg concentrations, however, this approach still presents challenges and reliable measurements typically require a Hg concentration \u22651 \u03bcg L\u22121 in the solution analyzed. Recent improvements of MC-ICP-MS instrumentation, including the introduction of the so-called Jet interface and 1013 \u03a9 Faraday cup amplifiers, enhance the signal-to-noise ratio. In this study, it was investigated to what extent this allows Hg isotopic analysis at lower concentration. Performance in Hg isotopic analysis was compared using two different sets of cones (standard vs. Jet), two plasma conditions (wet vs. dry) and two amplifier types (1011 \u03a9 vs. 1013 \u03a9). Satisfactory accuracy and precision were achieved at a Hg concentration down to 0.1 \u03bcg L\u22121 in the solution measured when using Jet cones, dry plasma conditions, and the four available 1013 \u03a9 amplifiers. The uncertainty expressed as 2SD for the \u03b4202Hg values measured for the in-house standard solution was \u00b10.2\u2030 at 0.25 \u03bcg Hg L\u22121 and \u00b1 0.3\u2030 at 0.1 \u03bcg Hg L\u22121. The method was subsequently applied to the analysis of real surface water samples contaminated with toxic metals.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('236','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_236\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D3JA00414G\" title=\"http:\/\/dx.doi.org\/10.1039\/D3JA00414G\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D3JA00414G<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D3JA00414G\" title=\"DOI de seguimiento:10.1039\/D3JA00414G\" target=\"_blank\">doi:10.1039\/D3JA00414G<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('236','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Rua-Ibarz, Ana;  Acker, Thibaut Van;  Bolea-Fernandez, Eduardo;  Boccongelli, Marina;  Vanhaecke, Frank<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('237','tp_links')\" style=\"cursor:pointer;\">A comparison of calibration strategies for quantitative laser ablation ICP-mass spectrometry (LA-ICP-MS) analysis of fused catalyst samples<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_volume\">vol. 39, <\/span><span class=\"tp_pub_additional_issue\">iss. 3, <\/span><span class=\"tp_pub_additional_pages\">pp. 888-899, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_237\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('237','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_237\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('237','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_237\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('237','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_237\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D3JA00271C,<br \/>\r\ntitle = {A comparison of calibration strategies for quantitative laser ablation ICP-mass spectrometry (LA-ICP-MS) analysis of fused catalyst samples},<br \/>\r\nauthor = {Ana Rua-Ibarz and Thibaut Van Acker and Eduardo Bolea-Fernandez and Marina Boccongelli and Frank Vanhaecke},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D3JA00271C},<br \/>\r\ndoi = {10.1039\/D3JA00271C},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\nurldate = {2024-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\nvolume = {39},<br \/>\r\nissue = {3},<br \/>\r\npages = {888-899},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {In the field of petrochemistry, the quantitative determination of trace elements in catalysts is crucial for optimizing various types of processes. Catalyst poisoning, resulting from the presence of contaminants, can lead to decreased performance and efficiency, even when these are present at trace level only. Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technique for trace elemental analysis, but its application to catalysts is challenging due to their physicochemical characteristics challenging straightforward dissolution. Laser ablation (LA) coupled to ICP-MS (LA-ICP-MS) has emerged as a valuable approach for direct analysis of solid samples. However, developing an appropriate calibration strategy for reliable quantitative LA-ICP-MS analysis of catalyst samples remains a challenge. In this work, different calibration strategies for quantitative LA-ICP-MS analysis of fused catalyst samples were evaluated. The traditional strategy relied on external calibration against certified reference materials (CRMs) combined with internal standardization and was considered the reference approach. When using this approach, the relative bias with respect to the reference value was found to be &lt;15%. Two novel calibration strategies were introduced and compared: a so-called multi-signal calibration approach and a solution-based calibration approach. The multi-signal calibration strategy involved varying the laser repetition rate (20, 30, 40 and 50 Hz) or laser beam diameter (10, 12, 15 and 20 \u03bcm), allowing a calibration curve to be constructed by comparing the analytical signal intensity for a single solid CRM with that for the sample, thus partially overcoming the shortage of CRMs for quantitative LA-ICP-MS analysis. The solution-based calibration approach was used for quantitative multi-element analysis without the need for any solid standard and required only minor hardware modifications to accommodate the introduction of aqueous standard solutions for calibration. Various glass certified reference materials were used for method development, calibration, and validation purposes. Furthermore, two fused alumina catalyst samples (used in the context of petroleum refining processes) were successfully analyzed as a proof-of-concept application. For both the multi-signal (matrix-matched conditions) and the solution-based calibration approaches, the average relative bias between the experimentally determined and certified\/reference concentrations varied between \u22129% and +7%.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('237','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_237\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In the field of petrochemistry, the quantitative determination of trace elements in catalysts is crucial for optimizing various types of processes. Catalyst poisoning, resulting from the presence of contaminants, can lead to decreased performance and efficiency, even when these are present at trace level only. Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technique for trace elemental analysis, but its application to catalysts is challenging due to their physicochemical characteristics challenging straightforward dissolution. Laser ablation (LA) coupled to ICP-MS (LA-ICP-MS) has emerged as a valuable approach for direct analysis of solid samples. However, developing an appropriate calibration strategy for reliable quantitative LA-ICP-MS analysis of catalyst samples remains a challenge. In this work, different calibration strategies for quantitative LA-ICP-MS analysis of fused catalyst samples were evaluated. The traditional strategy relied on external calibration against certified reference materials (CRMs) combined with internal standardization and was considered the reference approach. When using this approach, the relative bias with respect to the reference value was found to be &lt;15%. Two novel calibration strategies were introduced and compared: a so-called multi-signal calibration approach and a solution-based calibration approach. The multi-signal calibration strategy involved varying the laser repetition rate (20, 30, 40 and 50 Hz) or laser beam diameter (10, 12, 15 and 20 \u03bcm), allowing a calibration curve to be constructed by comparing the analytical signal intensity for a single solid CRM with that for the sample, thus partially overcoming the shortage of CRMs for quantitative LA-ICP-MS analysis. The solution-based calibration approach was used for quantitative multi-element analysis without the need for any solid standard and required only minor hardware modifications to accommodate the introduction of aqueous standard solutions for calibration. Various glass certified reference materials were used for method development, calibration, and validation purposes. Furthermore, two fused alumina catalyst samples (used in the context of petroleum refining processes) were successfully analyzed as a proof-of-concept application. For both the multi-signal (matrix-matched conditions) and the solution-based calibration approaches, the average relative bias between the experimentally determined and certified\/reference concentrations varied between \u22129% and +7%.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('237','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_237\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D3JA00271C\" title=\"http:\/\/dx.doi.org\/10.1039\/D3JA00271C\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D3JA00271C<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D3JA00271C\" title=\"DOI de seguimiento:10.1039\/D3JA00271C\" target=\"_blank\">doi:10.1039\/D3JA00271C<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('237','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bolea-Fernandez, Eduardo;  Rua-Ibarz, Ana;  Anjos, Jorge Alves;  Vanhaecke, Frank<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('238','tp_links')\" style=\"cursor:pointer;\">Development and initial evaluation of a combustion-based sample introduction system for direct isotopic analysis of mercury in solid samples via multi-collector ICP-mass spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Talanta, <\/span><span class=\"tp_pub_additional_volume\">vol. 276, <\/span><span class=\"tp_pub_additional_pages\">pp. 126210, <\/span><span class=\"tp_pub_additional_year\">2024<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 0039-9140<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_238\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('238','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_238\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('238','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_238\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('238','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_238\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{BOLEAFERNANDEZ2024126210,<br \/>\r\ntitle = {Development and initial evaluation of a combustion-based sample introduction system for direct isotopic analysis of mercury in solid samples via multi-collector ICP-mass spectrometry},<br \/>\r\nauthor = {Eduardo Bolea-Fernandez and Ana Rua-Ibarz and Jorge Alves Anjos and Frank Vanhaecke},<br \/>\r\nurl = {https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914024005897},<br \/>\r\ndoi = {https:\/\/doi.org\/10.1016\/j.talanta.2024.126210},<br \/>\r\nissn = {0039-9140},<br \/>\r\nyear  = {2024},<br \/>\r\ndate = {2024-01-01},<br \/>\r\nurldate = {2024-01-01},<br \/>\r\njournal = {Talanta},<br \/>\r\nvolume = {276},<br \/>\r\npages = {126210},<br \/>\r\nabstract = {High-precision isotopic analysis of mercury (Hg) using multi-collector ICP-mass spectrometry (MC-ICP-MS) is a powerful method for obtaining insight into the sources, pathways and sinks of this toxic metal. Modification of a commercially available mercury analyzer (Teledyne Leeman Labs, Hydra IIc \u2013 originally designed for quantification of Hg through sample combustion, collection of the Hg vapor on a gold amalgamator, subsequent controlled release of Hg and detection using cold vapor atomic absorption spectrometry CVAAS) enabled the system to be used for the direct high-precision Hg isotopic analysis of solid samples using MC-ICP-MS \u2013 i.e., without previous sample digestion and subsequent dilution. The changes made to the mercury analyzer did not compromise its (simultaneous) use for Hg quantification via CVAAS. The Hg vapor was mixed with a Tl-containing aerosol produced via pneumatic nebulization, creating wet plasma conditions, and enabling the use of Tl as an internal standard for correction of instrumental mass discrimination. Accurate and precise (0.10 \u2030 2SD, \u03b4202Hg},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('238','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_238\" style=\"display:none;\"><div class=\"tp_abstract_entry\">High-precision isotopic analysis of mercury (Hg) using multi-collector ICP-mass spectrometry (MC-ICP-MS) is a powerful method for obtaining insight into the sources, pathways and sinks of this toxic metal. Modification of a commercially available mercury analyzer (Teledyne Leeman Labs, Hydra IIc \u2013 originally designed for quantification of Hg through sample combustion, collection of the Hg vapor on a gold amalgamator, subsequent controlled release of Hg and detection using cold vapor atomic absorption spectrometry CVAAS) enabled the system to be used for the direct high-precision Hg isotopic analysis of solid samples using MC-ICP-MS \u2013 i.e., without previous sample digestion and subsequent dilution. The changes made to the mercury analyzer did not compromise its (simultaneous) use for Hg quantification via CVAAS. The Hg vapor was mixed with a Tl-containing aerosol produced via pneumatic nebulization, creating wet plasma conditions, and enabling the use of Tl as an internal standard for correction of instrumental mass discrimination. Accurate and precise (0.10 \u2030 2SD, \u03b4202Hg<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('238','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_238\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914024005897\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914024005897\" target=\"_blank\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039914024005897<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/https:\/\/doi.org\/10.1016\/j.talanta.2024.126210\" title=\"DOI de seguimiento:https:\/\/doi.org\/10.1016\/j.talanta.2024.126210\" target=\"_blank\">doi:https:\/\/doi.org\/10.1016\/j.talanta.2024.126210<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('238','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><h3 class=\"tp_h3\" id=\"tp_h3_2023\">2023<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Acker, Thibaut Van;  Rua-Ibarz, Ana;  Vanhaecke, Frank;  Bolea-Fernandez, Eduardo<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('223','tp_links')\" style=\"cursor:pointer;\">Laser Ablation for Nondestructive Sampling of Microplastics in Single-Particle ICP-Mass Spectrometry<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Anal. Chem., <\/span><span class=\"tp_pub_additional_volume\">vol. 95, <\/span><span class=\"tp_pub_additional_issue\">iss. 50, <\/span><span class=\"tp_pub_additional_pages\">pp. 18579-18586, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_223\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('223','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_223\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('223','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_223\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('223','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_223\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Laser Ablation for Nondestructive Sampling of Microplastics in Single-Particle ICP-Mass Spectrometry},<br \/>\r\nauthor = {Thibaut Van Acker and Ana Rua-Ibarz and Frank Vanhaecke and Eduardo Bolea-Fernandez},<br \/>\r\nurl = {https:\/\/doi.org\/10.1021\/acs.analchem.3c04473},<br \/>\r\ndoi = {10.1021\/acs.analchem.3c04473},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-12-05},<br \/>\r\nurldate = {2023-12-05},<br \/>\r\njournal = {Anal. Chem.},<br \/>\r\nvolume = {95},<br \/>\r\nissue = {50},<br \/>\r\npages = {18579-18586},<br \/>\r\nabstract = {In this work, laser ablation (LA) was characterized as a method for sampling and introducing microplastic particles (MPs) into an inductively coupled plasma (ICP) for subsequent 13C+ monitoring using an ICP-mass spectrometer operated in single-event mode. MPs of different types (PS, PMMA, and PVC) and sizes (2\u201320 \u03bcm) were introduced intactly. The laser energy density did not affect the particle sampling across a wide range (0.25\u20136.00 J cm\u20132). Single-shot analysis separated clustered MPs (2\u20137 MPs per cluster) during the LA and particle transport processes, allowing the temporally resolved analysis of the individual constituting MPs. Line scanning showed superior performance when using a small laser beam diameter combined with a high repetition rate. The 13C+ signal intensity correlated linearly (R2 &gt;0.9945) with the absolute C mass in a 2\u201310 \u03bcm size range, while the use of He in the collision-reaction cell (CRC) allowed extension of the linear range to 20 \u03bcm. The LA approach generated narrower 13C+ signal distributions than the traditional solution-based approach (dry versus wet plasma conditions) and proved successful for the analysis of a mixed suspension (containing four sizes of PS MPs in a 2\u20135 \u03bcm size range) and for sampling MPs from PVDF and glass microfiber filters, with the latter offering a lower background.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('223','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_223\" style=\"display:none;\"><div class=\"tp_abstract_entry\">In this work, laser ablation (LA) was characterized as a method for sampling and introducing microplastic particles (MPs) into an inductively coupled plasma (ICP) for subsequent 13C+ monitoring using an ICP-mass spectrometer operated in single-event mode. MPs of different types (PS, PMMA, and PVC) and sizes (2\u201320 \u03bcm) were introduced intactly. The laser energy density did not affect the particle sampling across a wide range (0.25\u20136.00 J cm\u20132). Single-shot analysis separated clustered MPs (2\u20137 MPs per cluster) during the LA and particle transport processes, allowing the temporally resolved analysis of the individual constituting MPs. Line scanning showed superior performance when using a small laser beam diameter combined with a high repetition rate. The 13C+ signal intensity correlated linearly (R2 &gt;0.9945) with the absolute C mass in a 2\u201310 \u03bcm size range, while the use of He in the collision-reaction cell (CRC) allowed extension of the linear range to 20 \u03bcm. The LA approach generated narrower 13C+ signal distributions than the traditional solution-based approach (dry versus wet plasma conditions) and proved successful for the analysis of a mixed suspension (containing four sizes of PS MPs in a 2\u20135 \u03bcm size range) and for sampling MPs from PVDF and glass microfiber filters, with the latter offering a lower background.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('223','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_223\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/doi.org\/10.1021\/acs.analchem.3c04473\" title=\"https:\/\/doi.org\/10.1021\/acs.analchem.3c04473\" target=\"_blank\">https:\/\/doi.org\/10.1021\/acs.analchem.3c04473<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1021\/acs.analchem.3c04473\" title=\"DOI de seguimiento:10.1021\/acs.analchem.3c04473\" target=\"_blank\">doi:10.1021\/acs.analchem.3c04473<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('223','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Sullivan, Kaj Vaughan;  Assantuh, Yasmina;  Grigoryan, Rosa;  Costas-Rodr\u00edguez, Marta;  Bolea-Fernandez, Eduardo;  Lapauw, Bruno;  Laecke, Steven Van;  Vanhaecke, Frank<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('235','tp_links')\" style=\"cursor:pointer;\">Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Int. J. Mol. Sci., <\/span><span class=\"tp_pub_additional_volume\">vol. 24, <\/span><span class=\"tp_pub_additional_issue\">iss. 21, <\/span><span class=\"tp_pub_additional_pages\">pp. 15683, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_235\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('235','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_235\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('235','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_235\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('235','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_235\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia},<br \/>\r\nauthor = {Kaj Vaughan Sullivan and Yasmina Assantuh and Rosa Grigoryan and Marta Costas-Rodr\u00edguez and Eduardo Bolea-Fernandez and Bruno Lapauw and Steven Van Laecke and Frank Vanhaecke},<br \/>\r\nurl = {https:\/\/doi.org\/10.3390\/ijms242115683},<br \/>\r\ndoi = {10.3390\/ijms242115683},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-10-27},<br \/>\r\nurldate = {2023-10-27},<br \/>\r\njournal = {Int. J. Mol. Sci.},<br \/>\r\nvolume = {24},<br \/>\r\nissue = {21},<br \/>\r\npages = {15683},<br \/>\r\nabstract = {Hypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection\/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection\/meal T1DM samples of 0.05 \u00b1 0.13\u2030 (1SD) was not significant. No difference was observed for controls before (\u22120.12 \u00b1 0.16\u2030) and after the meal (\u22120.10 \u00b1 0.13\u2030) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('235','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_235\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Hypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection\/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection\/meal T1DM samples of 0.05 \u00b1 0.13\u2030 (1SD) was not significant. No difference was observed for controls before (\u22120.12 \u00b1 0.16\u2030) and after the meal (\u22120.10 \u00b1 0.13\u2030) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('235','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_235\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/doi.org\/10.3390\/ijms242115683\" title=\"https:\/\/doi.org\/10.3390\/ijms242115683\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms242115683<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.3390\/ijms242115683\" title=\"DOI de seguimiento:10.3390\/ijms242115683\" target=\"_blank\">doi:10.3390\/ijms242115683<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('235','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Aramend\u00eda, Maite;  Leite, Diego;  Resano, Javier;  Resano, Mart\u00edn;  Billimoria, Kharmen;  Goenaga-Infante, Heidi<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('222','tp_links')\" style=\"cursor:pointer;\">Isotope Dilution Analysis for Particle Mass Determination Using Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry: Application to Size Determination of Silver Nanoparticles<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Nanomaterials, <\/span><span class=\"tp_pub_additional_volume\">vol. 13, <\/span><span class=\"tp_pub_additional_issue\">iss. 17, <\/span><span class=\"tp_pub_additional_pages\">pp. 2392, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_222\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('222','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_222\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('222','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_222\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('222','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_222\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nokey,<br \/>\r\ntitle = {Isotope Dilution Analysis for Particle Mass Determination Using Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry: Application to Size Determination of Silver Nanoparticles},<br \/>\r\nauthor = {Maite Aramend\u00eda and Diego Leite and Javier Resano and Mart\u00edn Resano and Kharmen Billimoria and Heidi Goenaga-Infante},<br \/>\r\ndoi = {10.3390\/nano13172392},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-08-22},<br \/>\r\nurldate = {2023-08-22},<br \/>\r\njournal = {Nanomaterials},<br \/>\r\nvolume = {13},<br \/>\r\nissue = {17},<br \/>\r\npages = {2392},<br \/>\r\nabstract = {This paper describes methodology based on the application of isotope dilution (ID) in<br \/>\r\nsingle-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-ToFMS) mode<br \/>\r\nfor the mass determination (and sizing) of silver nanoparticles (AgNPs). For this purpose, and<br \/>\r\nconsidering that the analytical signal in spICP-MS shows a transient nature, an isotope dilution<br \/>\r\nequation used for online work was adapted and used for the mass determination of individual NPs.<br \/>\r\nThe method proposed measures NP isotope ratios in a particle-to-particle approach, which allows for<br \/>\r\nthe characterization of NP mass (and size) distributions and not only the mean size of the distribution.<br \/>\r\nFor the best results to be obtained, our method development (undertaken through the analysis of<br \/>\r\nthe reference material NIST RM 8017) included the optimization of the working conditions for the<br \/>\r\nbest precision and accuracy in isotope ratios of individual NPs, which had been only reported to<br \/>\r\ndate with multicollector instruments. It is shown that the precision of the measurement of these<br \/>\r\nratios is limited by the magnitude of the signals obtained for each NP in the mass analyzer (counting<br \/>\r\nstatistics). However, the uncertainty obtained for the sizing of NPs in this approach can be improved<br \/>\r\nby careful method optimization, where the most important parameters are shown to be the selection<br \/>\r\nof the spike isotopic composition and concentration. Although only AgNPs were targeted in this<br \/>\r\nstudy, the method presented, with the corresponding adaptations, could be applied to NPs of any<br \/>\r\nother composition that include an element with different naturally available isotopes.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('222','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_222\" style=\"display:none;\"><div class=\"tp_abstract_entry\">This paper describes methodology based on the application of isotope dilution (ID) in<br \/>\r\nsingle-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-ToFMS) mode<br \/>\r\nfor the mass determination (and sizing) of silver nanoparticles (AgNPs). For this purpose, and<br \/>\r\nconsidering that the analytical signal in spICP-MS shows a transient nature, an isotope dilution<br \/>\r\nequation used for online work was adapted and used for the mass determination of individual NPs.<br \/>\r\nThe method proposed measures NP isotope ratios in a particle-to-particle approach, which allows for<br \/>\r\nthe characterization of NP mass (and size) distributions and not only the mean size of the distribution.<br \/>\r\nFor the best results to be obtained, our method development (undertaken through the analysis of<br \/>\r\nthe reference material NIST RM 8017) included the optimization of the working conditions for the<br \/>\r\nbest precision and accuracy in isotope ratios of individual NPs, which had been only reported to<br \/>\r\ndate with multicollector instruments. It is shown that the precision of the measurement of these<br \/>\r\nratios is limited by the magnitude of the signals obtained for each NP in the mass analyzer (counting<br \/>\r\nstatistics). However, the uncertainty obtained for the sizing of NPs in this approach can be improved<br \/>\r\nby careful method optimization, where the most important parameters are shown to be the selection<br \/>\r\nof the spike isotopic composition and concentration. Although only AgNPs were targeted in this<br \/>\r\nstudy, the method presented, with the corresponding adaptations, could be applied to NPs of any<br \/>\r\nother composition that include an element with different naturally available isotopes.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('222','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_222\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.3390\/nano13172392\" title=\"DOI de seguimiento:10.3390\/nano13172392\" target=\"_blank\">doi:10.3390\/nano13172392<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('222','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Aramend\u00eda, Maite;  Nakadi, Fl\u00e1vio V.;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('221','tp_links')\" style=\"cursor:pointer;\">An Approach Based on an Increased Bandpass for Enabling the Use of Internal Standards in Single Particle ICP-MS: Application to AuNPs Characterization<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">Nanomaterials, <\/span><span class=\"tp_pub_additional_volume\">vol. 13, <\/span><span class=\"tp_pub_additional_number\">no 12, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>, <span class=\"tp_pub_additional_issn\">ISSN: 2079-4991<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_221\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('221','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_221\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('221','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_221\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('221','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_221\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{nano13121838,<br \/>\r\ntitle = {An Approach Based on an Increased Bandpass for Enabling the Use of Internal Standards in Single Particle ICP-MS: Application to AuNPs Characterization},<br \/>\r\nauthor = {Antonio Bazo and Maite Aramend\u00eda and Fl\u00e1vio V. Nakadi and Mart\u00edn Resano},<br \/>\r\nurl = {https:\/\/www.mdpi.com\/2079-4991\/13\/12\/1838},<br \/>\r\ndoi = {10.3390\/nano13121838},<br \/>\r\nissn = {2079-4991},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-01-01},<br \/>\r\nurldate = {2023-01-01},<br \/>\r\njournal = {Nanomaterials},<br \/>\r\nvolume = {13},<br \/>\r\nnumber = {12},<br \/>\r\nabstract = {This paper proposes a novel approach to implement an internal standard (IS) correction in single particle inductively coupled plasma mass spectrometry (SP ICP-MS), as exemplified for the characterization of Au nanoparticles (NPs) in complex matrices. This approach is based on the use of the mass spectrometer (quadrupole) in bandpass mode, enhancing the sensitivity for the monitoring of AuNPs while also allowing for the detection of PtNPs in the same measurement run, such that they can serve as an internal standard. The performance of the method developed was proved for three different matrices: pure water, a 5 g L&minus;1 NaCl water solution, and another water solution containing 2.5% (m\/v) tetramethylammonium hydroxide (TMAH)\/0.1% Triton X-100. It was observed that matrix-effects impacted both the sensitivity of the NPs and their transport efficiencies. To circumvent this problem, two methods were used to determine the TE: the particle size method for sizing and the dynamic mass flow method for the determination of the particle number concentration (PNC). This fact, together with the use of the IS, enabled us to attain accurate results in all cases, both for sizing and for the PNC determination. Additionally, the use of the bandpass mode provides additional flexibility for this characterization, as it is possible to easily tune the sensitivity achieved for each NP type to ensure that their distributions are sufficiently resolved.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('221','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_221\" style=\"display:none;\"><div class=\"tp_abstract_entry\">This paper proposes a novel approach to implement an internal standard (IS) correction in single particle inductively coupled plasma mass spectrometry (SP ICP-MS), as exemplified for the characterization of Au nanoparticles (NPs) in complex matrices. This approach is based on the use of the mass spectrometer (quadrupole) in bandpass mode, enhancing the sensitivity for the monitoring of AuNPs while also allowing for the detection of PtNPs in the same measurement run, such that they can serve as an internal standard. The performance of the method developed was proved for three different matrices: pure water, a 5 g L&amp;minus;1 NaCl water solution, and another water solution containing 2.5% (m\/v) tetramethylammonium hydroxide (TMAH)\/0.1% Triton X-100. It was observed that matrix-effects impacted both the sensitivity of the NPs and their transport efficiencies. To circumvent this problem, two methods were used to determine the TE: the particle size method for sizing and the dynamic mass flow method for the determination of the particle number concentration (PNC). This fact, together with the use of the IS, enabled us to attain accurate results in all cases, both for sizing and for the PNC determination. Additionally, the use of the bandpass mode provides additional flexibility for this characterization, as it is possible to easily tune the sensitivity achieved for each NP type to ensure that their distributions are sufficiently resolved.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('221','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_221\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/www.mdpi.com\/2079-4991\/13\/12\/1838\" title=\"https:\/\/www.mdpi.com\/2079-4991\/13\/12\/1838\" target=\"_blank\">https:\/\/www.mdpi.com\/2079-4991\/13\/12\/1838<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.3390\/nano13121838\" title=\"DOI de seguimiento:10.3390\/nano13121838\" target=\"_blank\">doi:10.3390\/nano13121838<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('221','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Garc\u00eda-Poyo, M. Carmen;  B\u00e9rail, Sylvain;  Ronzani, Anne Laure;  Rello, Luis;  Garc\u00eda-Gonz\u00e1lez, Elena;  Nakadi, Fl\u00e1vio V.;  Aramend\u00eda, Maite;  Resano, Javier;  Resano, Mart\u00edn;  P\u00e9cheyran, Christophe<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('220','tp_links')\" style=\"cursor:pointer;\">Cu fractionation, isotopic analysis, and data processing via machine learning: new approaches for the diagnosis and follow up of Wilson&#039;s disease via ICP-MS<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_volume\">vol. 38, <\/span><span class=\"tp_pub_additional_issue\">iss. 1, <\/span><span class=\"tp_pub_additional_pages\">pp. 229-242, <\/span><span class=\"tp_pub_additional_year\">2023<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_220\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('220','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_220\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('220','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_220\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('220','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_220\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D2JA00267A,<br \/>\r\ntitle = {Cu fractionation, isotopic analysis, and data processing via machine learning: new approaches for the diagnosis and follow up of Wilson&#039;s disease via ICP-MS},<br \/>\r\nauthor = {M. Carmen Garc\u00eda-Poyo and Sylvain B\u00e9rail and Anne Laure Ronzani and Luis Rello and Elena Garc\u00eda-Gonz\u00e1lez and Fl\u00e1vio V. Nakadi and Maite Aramend\u00eda and Javier Resano and Mart\u00edn Resano and Christophe P\u00e9cheyran},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D2JA00267A},<br \/>\r\ndoi = {10.1039\/D2JA00267A},<br \/>\r\nyear  = {2023},<br \/>\r\ndate = {2023-01-01},<br \/>\r\nurldate = {2023-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\nvolume = {38},<br \/>\r\nissue = {1},<br \/>\r\npages = {229-242},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {Information about Cu fractionation and Cu isotopic composition can be paramount when investigating Wilson&#039;s disease (WD). This information can provide a better understanding of the metabolism of Cu. Most importantly, it may provide an easy way to diagnose and to follow the evolution of WD patients. For such purposes, protocols for Cu determination and Cu isotopic analysis via inductively coupled plasma mass spectrometry were investigated in this work, both in bulk serum and in the exchangeable copper (CuEXC) fractions. The CuEXC protocol provided satisfactory recovery values. Also, no significant mass fractionation during the whole analytical procedure (CuEXC production and\/or Cu isolation) was detected. Analyses were carried out in controls (healthy persons), newborns, patients with hepatic disorders, and WD patients. While the results for Cu isotopic analysis are relevant (e.g., \u03b465Cu values were lower for both WD patients under chelating treatment and patients with hepatic problems in comparison with those values obtained for WD patients under Zn treatments, controls, and newborns) to comprehend Cu metabolism and to follow up the disease, the parameter that can help to better discern between WD patients and the rest of the patients tested (non-WD) was found to be the REC (relative exchangeable Cu). In this study, all the WD patients showed a REC higher than 17%, while the rest showed lower values. However, since establishing a universal threshold is complicated, machine learning was investigated to produce a model that can differentiate between WD and non-WD samples with excellent results (100% accuracy, albeit for a limited sample set). Most importantly, unlike other ML approaches, our model can also provide an uncertainty metric to indicate the reliability of the prediction, overall opening new ways to diagnose WD.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('220','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_220\" style=\"display:none;\"><div class=\"tp_abstract_entry\">Information about Cu fractionation and Cu isotopic composition can be paramount when investigating Wilson&#039;s disease (WD). This information can provide a better understanding of the metabolism of Cu. Most importantly, it may provide an easy way to diagnose and to follow the evolution of WD patients. For such purposes, protocols for Cu determination and Cu isotopic analysis via inductively coupled plasma mass spectrometry were investigated in this work, both in bulk serum and in the exchangeable copper (CuEXC) fractions. The CuEXC protocol provided satisfactory recovery values. Also, no significant mass fractionation during the whole analytical procedure (CuEXC production and\/or Cu isolation) was detected. Analyses were carried out in controls (healthy persons), newborns, patients with hepatic disorders, and WD patients. While the results for Cu isotopic analysis are relevant (e.g., \u03b465Cu values were lower for both WD patients under chelating treatment and patients with hepatic problems in comparison with those values obtained for WD patients under Zn treatments, controls, and newborns) to comprehend Cu metabolism and to follow up the disease, the parameter that can help to better discern between WD patients and the rest of the patients tested (non-WD) was found to be the REC (relative exchangeable Cu). In this study, all the WD patients showed a REC higher than 17%, while the rest showed lower values. However, since establishing a universal threshold is complicated, machine learning was investigated to produce a model that can differentiate between WD and non-WD samples with excellent results (100% accuracy, albeit for a limited sample set). Most importantly, unlike other ML approaches, our model can also provide an uncertainty metric to indicate the reliability of the prediction, overall opening new ways to diagnose WD.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('220','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_220\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D2JA00267A\" title=\"http:\/\/dx.doi.org\/10.1039\/D2JA00267A\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D2JA00267A<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D2JA00267A\" title=\"DOI de seguimiento:10.1039\/D2JA00267A\" target=\"_blank\">doi:10.1039\/D2JA00267A<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('220','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><h3 class=\"tp_h3\" id=\"tp_h3_2022\">2022<\/h3><div class=\"tp_publication tp_publication_article\"><div class=\"tp_pub_info\"><p class=\"tp_pub_author\"> Bazo, Antonio;  Garde, Ra\u00fal;  Garcia-Ruiz, Esperanza;  Aramend\u00eda, Maite;  Nakadi, Fl\u00e1vio V.;  Resano, Mart\u00edn<\/p><p class=\"tp_pub_title\"><a class=\"tp_title_link\" onclick=\"teachpress_pub_showhide('219','tp_links')\" style=\"cursor:pointer;\">High-resolution continuum source graphite furnace molecular absorption spectrometry for the monitoring of Sr isotopes via SrF formation: a case study<\/a> <span class=\"tp_pub_type tp_  article\">Art\u00edculo de revista<\/span> <\/p><p class=\"tp_pub_additional\"><span class=\"tp_pub_additional_in\">En: <\/span><span class=\"tp_pub_additional_journal\">J. Anal. At. Spectrom., <\/span><span class=\"tp_pub_additional_volume\">vol. 37, <\/span><span class=\"tp_pub_additional_issue\">iss. 12, <\/span><span class=\"tp_pub_additional_pages\">pp. 2517-2528, <\/span><span class=\"tp_pub_additional_year\">2022<\/span>.<\/p><p class=\"tp_pub_menu\"><span class=\"tp_abstract_link\"><a id=\"tp_abstract_sh_219\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('219','tp_abstract')\" title=\"Mostrar resumen\" style=\"cursor:pointer;\">Resumen<\/a><\/span> | <span class=\"tp_resource_link\"><a id=\"tp_links_sh_219\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('219','tp_links')\" title=\"Mostrar enlaces y recursos\" style=\"cursor:pointer;\">Enlaces<\/a><\/span> | <span class=\"tp_bibtex_link\"><a id=\"tp_bibtex_sh_219\" class=\"tp_show\" onclick=\"teachpress_pub_showhide('219','tp_bibtex')\" title=\"Mostrar entrada BibTeX \" style=\"cursor:pointer;\">BibTeX<\/a><\/span><\/p><div class=\"tp_bibtex\" id=\"tp_bibtex_219\" style=\"display:none;\"><div class=\"tp_bibtex_entry\"><pre>@article{D2JA00245K,<br \/>\r\ntitle = {High-resolution continuum source graphite furnace molecular absorption spectrometry for the monitoring of Sr isotopes via SrF formation: a case study},<br \/>\r\nauthor = {Antonio Bazo and Ra\u00fal Garde and Esperanza Garcia-Ruiz and Maite Aramend\u00eda and Fl\u00e1vio V. Nakadi and Mart\u00edn Resano},<br \/>\r\nurl = {http:\/\/dx.doi.org\/10.1039\/D2JA00245K},<br \/>\r\ndoi = {10.1039\/D2JA00245K},<br \/>\r\nyear  = {2022},<br \/>\r\ndate = {2022-01-01},<br \/>\r\nurldate = {2022-01-01},<br \/>\r\njournal = {J. Anal. At. Spectrom.},<br \/>\r\nvolume = {37},<br \/>\r\nissue = {12},<br \/>\r\npages = {2517-2528},<br \/>\r\npublisher = {The Royal Society of Chemistry},<br \/>\r\nabstract = {High-resolution continuum source graphite furnace molecular absorption spectrometry (HR CS GFMAS) can provide isotopic information under certain conditions, thus broadening its field of application. However, to date, only elements with two major stable isotopes have been monitored via this technique. In this work, the possibilities of HR CS GFMAS to determine isotope ratios of elements with more than two stable isotopes are evaluated for the first time. For this purpose, Sr was chosen as the analyte and SrF as the target species, so four different signals corresponding to four stable Sr isotopes (88Sr, 87Sr, 86Sr and 84Sr) should be distinguished. Nevertheless, due to the number of strontium isotopes, the shape of the peaks, and the resolution that the instrument exhibits in the spectral window, isotopic signals overlap, thus leading to potentially biased results. To circumvent this issue, a deconvolution protocol, consisting of measuring and correcting for the contribution of each isotope on the signals of the rest, was developed. These contributions were calculated as the signal ratio between the absorbance of the monoisotopic profile at the wavelengths where the maxima of other isotopes are expected and at its own maximum. Therefore, the interference can be simply subtracted from the net signal registered for the interfered isotope. The performance of this method was demonstrated for both naturally abundant and isotope-enriched Sr standards, paving the way for future applications in this field. Analysis of a real sample (tap water) spiked with a 84Sr solution is also demonstrated.},<br \/>\r\nkeywords = {},<br \/>\r\npubstate = {published},<br \/>\r\ntppubtype = {article}<br \/>\r\n}<br \/>\r\n<\/pre><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('219','tp_bibtex')\">Cerrar<\/a><\/p><\/div><div class=\"tp_abstract\" id=\"tp_abstract_219\" style=\"display:none;\"><div class=\"tp_abstract_entry\">High-resolution continuum source graphite furnace molecular absorption spectrometry (HR CS GFMAS) can provide isotopic information under certain conditions, thus broadening its field of application. However, to date, only elements with two major stable isotopes have been monitored via this technique. In this work, the possibilities of HR CS GFMAS to determine isotope ratios of elements with more than two stable isotopes are evaluated for the first time. For this purpose, Sr was chosen as the analyte and SrF as the target species, so four different signals corresponding to four stable Sr isotopes (88Sr, 87Sr, 86Sr and 84Sr) should be distinguished. Nevertheless, due to the number of strontium isotopes, the shape of the peaks, and the resolution that the instrument exhibits in the spectral window, isotopic signals overlap, thus leading to potentially biased results. To circumvent this issue, a deconvolution protocol, consisting of measuring and correcting for the contribution of each isotope on the signals of the rest, was developed. These contributions were calculated as the signal ratio between the absorbance of the monoisotopic profile at the wavelengths where the maxima of other isotopes are expected and at its own maximum. Therefore, the interference can be simply subtracted from the net signal registered for the interfered isotope. The performance of this method was demonstrated for both naturally abundant and isotope-enriched Sr standards, paving the way for future applications in this field. Analysis of a real sample (tap water) spiked with a 84Sr solution is also demonstrated.<\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('219','tp_abstract')\">Cerrar<\/a><\/p><\/div><div class=\"tp_links\" id=\"tp_links_219\" style=\"display:none;\"><div class=\"tp_links_entry\"><ul class=\"tp_pub_list\"><li><i class=\"fas fa-globe\"><\/i><a class=\"tp_pub_list\" href=\"http:\/\/dx.doi.org\/10.1039\/D2JA00245K\" title=\"http:\/\/dx.doi.org\/10.1039\/D2JA00245K\" target=\"_blank\">http:\/\/dx.doi.org\/10.1039\/D2JA00245K<\/a><\/li><li><i class=\"ai ai-doi\"><\/i><a class=\"tp_pub_list\" href=\"https:\/\/dx.doi.org\/10.1039\/D2JA00245K\" title=\"DOI de seguimiento:10.1039\/D2JA00245K\" target=\"_blank\">doi:10.1039\/D2JA00245K<\/a><\/li><\/ul><\/div><p class=\"tp_close_menu\"><a class=\"tp_close\" onclick=\"teachpress_pub_showhide('219','tp_links')\">Cerrar<\/a><\/p><\/div><\/div><\/div><\/div><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":3895,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[226,230],"tags":[],"class_list":["post-3893","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-projects","category-projects"],"_links":{"self":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=3893"}],"version-history":[{"count":10,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3893\/revisions"}],"predecessor-version":[{"id":4405,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/posts\/3893\/revisions\/4405"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/media\/3895"}],"wp:attachment":[{"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=3893"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=3893"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/marte.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=3893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}